Evaluation of efficacy of topiramate with supplement riboflavin in pediatric migraine prophylaxis
- سال انتشار: 1398
- محل انتشار: نوزدهمین کنگره سالانه اعصاب کودکان ایران
- کد COI اختصاصی: CCNMED19_076
- زبان مقاله: انگلیسی
- تعداد مشاهده: 157
نویسندگان
Professor, Pediatric Neurologist, Department of Pediatrics, Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
چکیده
Introduction: Migraine as the most common primary headache in children occur up to۱۰.۶ % of ۵-۱۵ year old children and today many nutraceutics and alternative remedieshave been used in migraine prophylaxis. The aim of present study was to evaluated efficacy and safety of topiramate plus supplement riboflavin in pediatric migraineprophylaxis. Methods: In a quasi- experimental study, monthly frequency, severity and duration of headache, migraine disability and clinical side effects of ۳ mg/kg topiramate with ۱۰۰ mg riboflavin daily for eight weeks in forty migraineur referred children to Pediatric Neurology Clinic of Shahid Sadoughi Medical Sciences University, Yazd, Iran from December ۲۰۱۸ October ۲۰۱۹ whom were treated with, were evaluated. Results: ۲۴ girls and ۱۶ boys with mean age of ۱۱.۳۲±۱.۳۲ were evaluated. Combination of topiramate with riboflavin was effective in reduction of monthly frequency (۱۶.۱۲±۶.۶۴ to ۸.۰۱±۳.۲۲ attacks) , severity (۷.۲۱±۰.۲۳ to ۴.۰۱±۱.۷۶scores), duration of headache reduced (۳.۷۸±۱.۲۲ to ۱.۰۱±۰.۸۹ hours) and Pediatric Migraine Disability Assessment score (۳۴.۱۳±۹.۳۶ to ۱۴.۲۸±۹.۷۹) and all p < ۰.۰۵. Good response (more than۵۰% reduction in monthly headache frequency) was seen in ۲۴ children (۶۰%). Nausea and mild diarrhea were seen in ۴ children (۱۰%), but, no serious side effects were seen in these children. Conclusion: Combination of topiramate and riboflavin is well tolerated and can be used as safe and efficient drug in pediatric migraine prophylaxis.کلیدواژه ها
Migraine, Prophylaxis, Pediatric, Topiramate, Riboflavin.مقالات مرتبط جدید
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