Identification of the Bacterial Meningitis agents in Children with Febrile Seizure

Introduction: About ۱ to ۵ percent of children with febrile seizures have central nervous system infection with meningitis, so the first step in these patients is to make thenecessary assessments to diagnose meningitis And then identification and detection the causative agents of this disease through cerebrospinal fluid (CSF) cultures obtainedthrough lumbar puncture. Bacterial meningitis is one of the most serious infections and should be treated as emergency. As it has significant morbidity and mortality throughout the world, every country should have precise information regarding the etiological agents of disease and populations at risk to design public health prevention strategy. The aim of this study was therefore identification of the bacterial meningitis agents in Children with Febrile Seizure. Methods: This research is a retrospective descriptive cross-sectional study. Cerebrospinal fluid were collected from ۱۸۲ pediatric patients at the age of ۵ months to ۶ years old with Febrile Seizure and suspected meningitis, ۱۱۴ of which were confirmed by biochemical, microbiological and molecular tests as bacterial meningitis. Results: All children with bacterial meningitis were under ۱۸ months of age and all presented with the first febrile seizure. ۵۲.۳% of the seizures were complex. According to the ۲-Chi test, there was a significant relationship between the type of seizure and the prevalence of meningitis and the type of seizure and the prevalence of bacterial meningitis in children with febrile Seizure (P value <۰.۰۵). ۵۲% of gram positive bacteria and ۴۸% of gram negative bacteria were isolated. The most common bacteria isolated were: Streptococcus pneumoniae ۲۸%, Staphylococcus aureus ۱۲.۵%, Escherichia coli ۹%, and Neisseria meningitidis۸% and Pseudomonas aeruginosa۶.۵%. Conclusion: According to the results of this study, specially Gram positive bacteria included Streptococcus pneumoniae and Staphylococcus aureus are major causes of bacterial meningitis in children.

کلیدواژه ها:

Bacterial Meningitis ، Febrile Seizure ، Children ، Cerebrospinal Fluid.