Amaranthus hybridus (Amaranthaceae) prevents the detrimental effects of cyclophosphamide on ovarian function in Wistar rats: An experimental study
- سال انتشار: 1401
- محل انتشار: International Journal of Reproductive BioMedicine، دوره: 20، شماره: 8
- کد COI اختصاصی: JR_IJRM-20-8_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 140
نویسندگان
Research Unit of Animal Physiology and Phytopharmacology (URPAP), Faculty of Science, University of Dschang, Dschang, Cameroon.
Prechmy Carole Nsamou Ngueyong
Research Unit of Animal Physiology and Phytopharmacology (URPAP), Faculty of Science, University of Dschang, Dschang, Cameroon.
Research Unit of Animal Physiology and Phytopharmacology (URPAP), Faculty of Science, University of Dschang, Dschang, Cameroon.
Research Unit of Animal Physiology and Phytopharmacology (URPAP), Faculty of Science, University of Dschang, Dschang, Cameroon.
Research Unit of Animal Physiology and Phytopharmacology (URPAP), Faculty of Science, University of Dschang, Dschang, Cameroon. Department of Biomedical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon.
Department of Animal Organisms Biology, University of Douala, Douala, Cameroon.
Department of Animal Biology and Physiology, University of Yaoundé ۱, Yaoundé, Cameroon.
چکیده
Background: Cyclophosphamide (CP) is an anticancer agent, but its chronic administration induces ovarian toxicity. Objective: We evaluated the effects of aqueous extract (AE) and methanol extract (ME) of Amaranthus hybridus (A. hybridus) on CP-induced ovarian toxicity in rats. Materials and Methods: ۴۰ female Wistar rats (۱۰ wk, ۱۷۰-۲۰۰ gr) were distributed into ۸ groups (n = ۵/each) as follows: ۱) healthy control; ۲) CP+distilled water (۱۰ ml/kg/d); ۳) CP+۳%-tween ۸۰ (۱۰ mL/kg/d); ۴) CP+clomiphene citrate (۲ mg/kg/d); ۵, ۶) CP+AE of A. hybridus (۵۵ and ۱۱۰ mg/kg/d); and ۷, ۸) CP+ME of A. hybridus (۵۵ and ۱۱۰ mg/kg/d). After ۲۸ days of treatment, estrus cyclicity, ovarian and uterine weights as well as estradiol levels and ovarian histology were determined. Results: CP induced ovarian toxicity after ۲۸ days of exposure. More specifically, CP disturbed the estrus cycle, decreased ovary and uterus weights (p = ۰.۰۴), and the ۱۷-β estradiol level (p = ۰.۰۴), and induced severe ovarian damages. Remarkably, A. hybridus significantly increased (p = ۰.۰۳) the ovarian weight (AE and ME at all doses) and uterus weight (ME at ۱۱۰ mg/kg/d), compared with the CP-treated rats. Moreover, the ۱۷-β estradiol level was significantly elevated (p = ۰.۰۲) in rats given clomiphene citrate and A. hybridus (AE ۱۱۰ mg/kg/d; ME ۵۵ mg/kg/d). Finally, the ovaries of rats given plant extracts had many corpus luteum and normal follicles, and no cystic follicles. Conclusion: A. hybridus prevented the detrimental effects of CP on ovarian function, which could support its traditional use as a fertility enhancer.کلیدواژه ها
Cyclophosphamide, Amaranthus hybridus, Toxicity, Estradiol, Rat., سیکلوفسفامید, تاج خروس سبز, سمیت, استرادیول, موش صحرایی.اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.