An epigenetic mechanism underlying non-Mendelianinheritance patterns
- سال انتشار: 1400
- محل انتشار: کنفرانس بین المللی ژنتیک و ژنومیکس انسانی
- کد COI اختصاصی: CHGGE01_106
- زبان مقاله: انگلیسی
- تعداد مشاهده: 233
نویسندگان
Biology department, Yazd University, Yazd, Iran
چکیده
Complex diseases often show some familial recurrences, but do not have aclear hereditary pattern. Genetic network interactions and regulatory factorssuch as non-coding RNAs can modify disease penetration and induceunpredictability. Epigenetic markings establish an inheritable pattern thataffects gene expression without altering its DNA sequence. These indicatorsare also influenced by environmental factors. Epigenetic tags are generallyerased in early embryos; nonetheless, transgenerational maintenance of themethylation pattern has been observed. Some specific regions, however,behave differently, such as the Imprinting Control Regions (ICRs) which areprotected from this reprogramming and are associated with gene imprintings.It has also been shown that some repetitive DNA sequences are partiallyresistant. Intracisternal A-particle (IAP) in Avy mice, for example, the degreeof IAP methylation varies dramatically between individuals, resulting in awide distribution of coat color. Since SINEs, VNTRs, and Alu elements arelikely to act in the same way in humans, their respective information couldtheoretically be inherited if the epigenetic states of the germline in these areaschange due to environmental influences. Researchers are looking for putative"metastable epialleles" in humans by identifying DNA methylation sites thatvary widely between groups of people but have minimal variation in thetissue types of each individual. This model suggests that methylation in theseareas is set stochastically early in embryonic development. Ultimately,longitudinal studies in multi-generational human populations are needed todetermine the extent of how much intergenerational and transgenerationalepigenetic inheritances contribute to human diseases.کلیدواژه ها
Epigenetics, Non-Mendelian, Inheritance, Metastable epiallelesمقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.