Single Nucleotide Polymorphisms as the EfficientPrognostic Markers in Breast Cancer

  • سال انتشار: 1400
  • محل انتشار: کنفرانس بین المللی ژنتیک و ژنومیکس انسانی
  • کد COI اختصاصی: CHGGE01_100
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 137
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نویسندگان

Maliheh Alimardani

Medical Genetics Research Center, School of Medicine, Mashhad University ofMedical Sciences, Mashhad, Iran . Department of Medical Genetics and Molecular Medicine, School of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran . Student Research

Meysam Moghbeli

Department of Medical Genetics and Molecular Medicine, School of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran

Azam Rastgar-Moghadam

Medical Genetics Research Center, School of Medicine, Mashhad University ofMedical Sciences, Mashhad, Iran

Fatemeh Homaei Shandiz

Department of Radiotherapy/Oncology, Omid Hospital, Mashhad University ofMedical Science, Mashhad, Iran

Mohammad Reza Abbaszadegan

Medical Genetics Research Center, School of Medicine, Mashhad University ofMedical Sciences, Mashhad, Iran . Department of Medical Genetics and Molecular Medicine, School of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran.Immunology Researc

چکیده

Breast cancer (BC) is known as the most common malignancy in women.Environmental and genetic factors are associated with BC progression.Genetic polymorphisms have been reported as important risk factors forBC prognosis and drug response. In the present review, we havesummarized all of the single nucleotide polymorphisms (SNPs) which havebeen significantly associated with drug response in BC patients in theworld. We have also categorized the reported SNPs based on their relatedgene functions to clarify the molecular biology of drug responses in BC.The majority of SNPs were reported in detoxifying enzymes whichintroduced such genes as the main genetic risk factors during BC drugresponses. This review paves the way for introducing a prognostic panel ofSNPs for the BC patients in the world.

کلیدواژه ها

Breast cancer, prognostic marker, chemoresistance, drugresponse, nucleotide polymorphisms, genetic polymorphism

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