FTO gene polymorphism (rs۱۵۵۸۹۰۲) and obesity inathletes and non-athletes individuals
محل انتشار: کنفرانس بین المللی ژنتیک و ژنومیکس انسانی
سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 66
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شناسه ملی سند علمی:
CHGGE01_062
تاریخ نمایه سازی: 22 شهریور 1401
چکیده مقاله:
About ۱.۴ billion people worldwide are overweight, of which one-third areobese. Overweight-related diseases such as type ۲ diabetes, cardiovasculardisease, and an increased risk of certain types of cancer not only reduce aperson's quality of life but also add a significant burden to the health andeconomic systems of communities. Obesity has a strong hereditarybackground, part of which is explained by the known single nucleotidepolymorphisms (SNPs). The gene most closely associated with humanobesity is the fat-related mass and obesity (FTO) gene. Although thefunctional role of FTO remains unclear, it has been shown to encode anenzyme capable of removing methyl groups from DNA. This feature suggeststhat obesity can be caused by epigenetic mechanisms. One of the majorepigenetic mechanisms is the methylation of cytosine DNA residues that mayreduce the transcription of genes near the methylation site. Extensivegenomic linkage studies have shown that SNP within the first FTO intron,rs۱۵۵۸۹۰۲ (T/A) is strongly associated with human obesity. Adults who arehomozygous for the A allele have been shown to weigh an average of ۱.۵ to ۳kg more than those for the homozygous T allele. Research studies showedthat exercise may reduce the association between A / T polymorphism andobesity-related traits. The association between A / T polymorphism and bodymass index (BMI) is significantly weaker in people with higher levels ofexercise. The results of these studies can be used to provide preventive andtherapeutic strategies against overweight and obesity in susceptibleindividuals.
نویسندگان
Sayedeh Maryam Hosseini Majd
Department of Genetics, Faculty of Biological Sciences and Technology, Shahid AshrafiEsfahani University, Isfahan, Iran
Hamid Galehdari
Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz,Ahvaz, Iran
Tahereh Sadeghian-Rizi
Department of Biotechnology, Faculty of Biological Sciences and Technology, ShahidAshrafi Esfahani University, Isfahan, Iran