Conjugation of Cortistatin Peptide with Gold Nanoparticles Synthesized to Investigate Anti-Inflammatory Effects in Allergic Asthma
- سال انتشار: 1402
- محل انتشار: مجله علوم دارویی و شیمی، دوره: 6، شماره: 1
- کد COI اختصاصی: JR_JMCH-6-1_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 263
نویسندگان
Department of Chemistry, Ilam Branch, Islamic Azad University, Ilam, Iran
Department of Chemistry, Ilam Branch, Islamic Azad University, Ilam, Iran
Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
چکیده
In this study, conjugation between Cortistatin peptide and gold nanoparticles was performed for effective drug delivery of peptide to lung tissue to investigate its anti-inflammatory anti-asthmatic effects. To create conjugation between metal nanoparticles and biomolecules, there are different strategies based on chemical or physical interactions, which are selected according to the desired goals. Attaches based on chemical interactions have more specificity and selectivity, and for the intended purpose, drug delivery to the lung tissue is more desirable. This work performed conjugation based on chemical interactions using linker molecules to achieve higher specificity and selectivity. The binding of Cortistatin peptide to gold nanoparticles in this work was ۸۰%, which indicates that the binding through the linker molecules is well done.کلیدواژه ها
Allergic Asthma, Neuropeptide, Gold Nanoparticles, treatment, anti-inflammatoryاطلاعات بیشتر در مورد COI
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