Vaccine-Associated Paralytic Poliomyelitis: A case report

Introduction: For as long as IRAN uses Oral polio vaccine (OPV; Containing live attenuated viruses), for expanded program on childhood immunization. The most severe complication caused by OPV is Vaccine-associated paralytic (VAPP). VAPP is more common in people with Immunodeficiency.Patient Report: The case is an Iranian infant, born on February ۲۱, ۲۰۱۸ and birth weight ۲۲۰۰gr., with cellular immune deficiency. Date of onset of paralysis is ۹۷ days after receiving the second dose of OPV at the age of ۷ months on October ۲, ۲۰۱۸. Paralysis of the respiratory muscles occurred with tachypnea and fever. According to the world protocol, two stool samples were taken from the patient. The results of both samples with both L۲۰B & RD cell line tests were Positive and vaccine-derived polio virus isolated from the patient's stool. The examinations done by the national referral laboratory of the Tehran University of medical sciences.Conclusion: A decrease in the Percent of children immunization coverage conduces to circulating Vaccine-Derived Polio Virus (cVDPV) as well as, viral excretion by people withimmune deficiency in the community. In addition to cause a poliomyelitis infection in these people, it can endangers the global polio eradication Initiative (GPEI).

کلیدواژه ها:

poliomyelitis ، oral polio vaccine ، inactivated polio vaccine ، vaccine-derived polio virus ، Vaccine-Associated Paralytic Polio