The Effects of Grape Seed Extract Consumption on hs-CRP and Lipid Profile in Young Men

Cardiovascular diseases especially atherosclerosis, are the main causative of disability and death in all over the world and they have increasing spread in Iran. Hs-CRP and Lipid profile are to risk factors for prediction of atherosclerosis. Grape seed extract has a very high potential in Reduce or inhibit of Hs-CRP and Lipid profile. The main aim of this study was to determine the effect of grape seed extract consumption on hs-CRP and Lipid Profile in young men.In this study,۳۰ healthy non-athlete male with an average age ۱۷-۲۳ randomly divided into three groups of supplement ۱, supplement ۲ and control. The program of consumption of grape seed extract was in supplement group ۱ (۴۰۰ mg per day), supplement group ۲ (۲۰۰ mg per day) for ۶ weeks while the placebo group received a corresponding placebo. Before and after the intervention, hs-CRP, TC, TG, HDL-C and LDL-C were measured. Data were statistically analyzed by one-way ANOVA and paired-samples T test methods (p<۰.۰۵).The results showed that consumption of grape seed extract in supplement groups ۱ and ۲ significantly reduced C-reactive protein and increased HDL-cholesterol, and only in supplement group ۱ caused a significant decrease in triglyceride, total cholesterol and LDL-cholesterol. However, no significant change was observed in the control group.The results showed that daily consumption of ۴۰۰ mg compared to ۲۰۰ mg of grape seed extract supplement for ۶ weeks had a better effect on reducing hs-CRP and lipid profile of young men. Therefore, daily consumption of ۴۰۰ mg of grape seed extract is recommended to reduce hs-CRP and lipid profile of young men. However, in order to be able to discuss and conclude with more certainty about the factors affecting the increase and decrease of these factors and its application in sports, more studies are needed.

کلیدواژه ها:

Grape seed extract ، C-reactive protein ، Lipid profile