Crosstalk Between Programmed Death Ligand ۱, Ki-۶۷ Labelling Index, and Tumor-Infiltrating Lymphocytes in Invasive Breast Cancer and Clinicopathological Correlations in a Tertiary Care Center in Western India

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 130

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شناسه ملی سند علمی:

JR_IJP-17-3_008

تاریخ نمایه سازی: 8 شهریور 1401

چکیده مقاله:

Background & Objective: Breast cancer is the leading cancer among Indian women and accounts for about ۲۵% of all cancer cases worldwide. The present study aimed to assess Programmed Death Ligand-۱ (PD-L۱) expression in tumoral cells and tumor-infiltrating lymphocytes (TILs) and evaluate their correlations with the Ki-۶۷ labelling index in invasive breast carcinomas (IBC).Methods: This descriptive observational study was conducted during ۲۰۱۶-۲۰۱۸ and included all diagnosed cases of IBC. The relationships between PD-L۱ expression, TILs, hormone receptors, Ki-۶۷, and clinicopathological parameters were studied in IBC. Statistical analysis was performed by SPSS version ۲۳.Results: Out of ۱۱۴ evaluated cases, ۳۳.۳۳% (N=۳۸) showed PD-L۱+ expression in tumor cells and ۴۷.۳۷% (N=۵۴) had PD-L۱+ expression in TILs. A high Ki-۶۷ index was observed in ۹۶ cases. Moreover, ۴۹ patients were estrogen receptor (ER)- and ۶۵ were ER+. We observed that ۲۲ of ۴۹ ER- and ۴۹ of ۶۵ ER+ subjects showed PD-L۱+ expression, respectively.Conclusion: Our results showed a significant relationship between PD-L۱ expression in tumoral cells and TILs, as well as between Ki-۶۷ and TILs. In addition, an inverse correlation was noted between PD-L۱ expression and ER. The PD-L۱ expression in tumors and TILs and correlation with high Ki-۶۷ may prove the importance of PD-L۱ in targeted chemotherapy. An inverse relationship between PD-L۱ and ER expression in tumoral cells suggests scope for immunotherapy in ER- IBC. However, further research with more cases is required.

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نویسندگان

Rashim Sharma

Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Poonam Elhence

Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Meenakshi Rao

Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Sudeep Khera

Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Deepak Vedant

Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Ramkaran Chaudhary

Department of General Surgery, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Puneet Pareek

Department of Radiation Oncology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Jeewan Vishnoi

Department of Surgical Oncology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Sanjeev Misra

Department of Surgical Oncology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

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