EFFECTS OF DIETARY CALCIUM ON CONCENTRATIONS OF LIPIDS, GLUCOSE AND INSULIN IN MALE SPRAGUE-DAWELY RATS

  • سال انتشار: 1386
  • محل انتشار: مجله آریا آترواسکلروز، دوره: 3، شماره: 1
  • کد COI اختصاصی: JR_RYA-3-1_005
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 191
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نویسندگان

Jan Mohammd Malekzadeh

Ph.D. Student of nutrition, Nutrition & Biochemistry Dept. School of Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Ali Keshavarz

PhD. Professor of nutrition, Nutrition & Biochemistry Dept. School of Health, TUMS.

Feridon Siassi

PhD. Professor of nutrition, Nutrition & Biochemistry Dept. School of Health, TUMS.

Mehri Kadkhodaei

PhD. Professor of Physiology, Physiology Dept., School of Medicine, TUMS.

Mohammad Reza Eshraghian

PhD. Professor of Statistics, Statistics and Epidemiology Dept., School of Health, TUMS.

Ahmad Reza Dorosti-Motlagh

PhD. Associate Professor of Nutrition, Nutrition and Biochemistry Dept., School of Health, TUMS.

Asghar Aliehpoor

MD. Assistant of Pathology, Pathology Dept., Shariaati Hospital, TUMS.

Maryam Chamari

M.Sc. Research Assistant, Nutrition & Biochemistry Dept., School of Health, TUMS.

چکیده

  Abstract INTRODUCTION: A number of experimental studies have shown that dietary calcium may help improve hypercholesterolemia induced by high-cholesterol/high-fat diets through saponifying cholesterol/fat in the intestine. There is little evidence showing the effect of calcium in a low-fat, low-cholesterol diet on the lipid profile. We evaluated the effect of different levels of dietary calcium, in a cholesterol-free/low-fat diet on serum cholesterol, triglyceride, glucose and insulin, as well as fecal excretion of lipids. methods: Forty-eight male Sprague-Dawely rats were randomly divided to receive three levels of dietary calcium (۰.۲, ۰.۵ and ۱.۲ % W/W) for ۱۰ weeks. Finally, the rats were decapitated and their truncal blood was sampled for biochemical analysis. Fecal fat excretion, total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, glucose, and serum insulin were measured. Low-density lipoprotein (LDL) cholesterol was calculated using the Friedwald equation. results: Serum cholesterol and LDL cholesterol of rats receiving a high-calcium diet were significantly lower than those of the other two groups (P< ۰.۰۵), but serum triglycerides, HDL cholesterol, glucose and insulin and fecal fat excretion were not statistically different in the three groups (P> ۰.۰۵). CONCLUSIONS: Our findings suggest that, even with a low-fat low-cholesterol diet, calcium has hypocholesterolemic effects, i.e. there may be hypocholesterolemic mechanisms, other than intestinal saponification of cholesterol and/or fatty acids, including endogenous mechanisms for dietary calcium.     Keywords: Dietary calcium, serum cholesterol, serum LDL cholesterol, serum triglycerides, serum glucose, serum insulin, fecal fat.

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