Nizal Sarrafzadegan - Professor, Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Masoumeh Sadeghi - Associate Professor, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Forough Khademi - Cardiologist, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences,Isfahan, Iran.
Mohammad Arash Ramezani - Specialist in Social Medicine, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
Mohammad Hashemi Jazi - Associated Professor, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

   BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Various studies showed relationship between electrocardiographic (ECG) changes at rest and CVD mortality. Present study was performed to find the relation between ECG and CVD risk factors in an Iranian population.    METHODS: This cross-sectional study was performed on ۳۳۴۳ subjects aged ≥ ۳۵ years from three provincial cities of Isfahan, Arak, and Najafabad. Demographic and lifestyle information, as well as weight, height, blood pressure, hip and waist circumference measurement was recorded. Laboratory tests including total cholesterol (TC), LDL-C, HDL-C, triglycerides (TG) and fasting serum glucose were measured too. Ischemic criteria of ECG included minor and major changes in ST segment, T wave, conductive disorders, blocks and arrhythmias.    RESULTS: Ischemic changes in women were ۱.۵ times more than men (P < ۰.۰۵). Mean age of  the group with ischemic findings was ۵ years more than non-Ischemic group. Comparison of lifestyle variables indicated that physical activity in reverse to nutrient index was significantly more in non-ischemic individuals compared to the ischemic individuals. Smoking showed a significant difference between the two groups, too (P < ۰.۰۵). Anthropometric variables including body mass index (BMI), hip and waist circumference and diabetic and systolic blood pressure as well as biochemical factors including TC, HDL-C, and LDL-C were significantly higher in Ischemic group (P < ۰.۰۵).    CONCLUSION: Considering the ischemic change in individuals with unhealthy life style or with CVD risk factors, these should be considered in evaluation of these patients.         Keywords: Ischemic Changes, Electrocardiography, Cardiovascular Risk Factors.