Acute and chronic effects of morphine on cardiovascular system and the baroreflexes sensitivity during severe increase in blood pressure in rats
- سال انتشار: 1390
- محل انتشار: مجله آریا آترواسکلروز، دوره: 7، شماره: 3
- کد COI اختصاصی: JR_RYA-7-3_005
- زبان مقاله: انگلیسی
- تعداد مشاهده: 133
نویسندگان
Associate Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
MD, Health City Center, Fereydonshahr, Iran
MSc in Physiology, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
BACKGROUND: This study aimed to determine the role and effects of baroreflexes duringacute increase in blood pressure (BP) after severe and long-term infusion of morphine.METHODS: This experimental study was conducted on male desert rats. They were assignedinto ۴ groups and the rats of the case group received morphine in the short and long termperiods, whereas the control rats received normal saline for the same duration. Then, the ratswere anesthetized, and their femoral artery and vein were cannulated for the injection ofphenylephrine and naloxone, respectively. The injection of phenylephrine was performed by thedevice after a period of recording BP, mean arterial pressure (MAP), heart rate (HR) andbaroreflex sensitivity (BRS) in order to induce acute hypertension before and after injectingnaloxone. The Student t-test and analysis of variance (ANOVA) were used for statistical analysis.RESULTS: The obtained results suggested that acute and chronic injections of morphine maycause significant reduction in systolic and diastolic arterial BP as well as the mean arterialpressure; moreover, it significantly increased the sensitivity of baroreflexes. Furthermore, theincreased baroreflex sensitivity was observed after acute injection of morphine, whereas chronicmorphine injection caused reduction in baroreflex sensitivity.CONCLUSION: It seems that the details of the opiates' effects on the body includingcardiovascular system depend on the type of opioids and consequently, on the type of stimulatedreceptor.Keywords: Morphine; Baroreflex Sensitivity; Blood Pressureکلیدواژه ها
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