Effect of conjugated linoleic acid and omega-۳ fatty acid supplementation on inflammatory and oxidative stress markers in atherosclerotic patients
محل انتشار: مجله آریا آترواسکلروز، دوره: 9، شماره: 6
سال انتشار: 1392
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 122
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شناسه ملی سند علمی:
JR_RYA-9-6_001
تاریخ نمایه سازی: 2 شهریور 1401
چکیده مقاله:
BACKGROUND: Cardiovascular disease is the major cause of morbidity, mortality, and disability in Iranian people. Inflammation and oxidative processes are key components of cardiovascular disease. The aim of this study was to evaluate the effect of conjugated linoleic acids (CLA) and omega-۳ fatty acid (ω-۳ fatty acids) supplementation on inflammation markers and oxidative stress in atherosclerotic patients. METHODS: This study was a two-month clinical, randomized trial. ۹۰ volunteers who referred to Emam Reza Heart Clinic of Shiraz University of Medical Sciences (Shiraz, Iran) from February to March ۲۰۱۱ and had the inclusion criteria of this study were selected. Participants were classified into ۳ groups receiving ۳ g/d CLA, ۱۹۲۰ mg/d ω-۳, or placebo for ۲ months. C-reactive protein (CRP), interleukin-۶ (IL-۶), malondialdehyde (MDA), and glutathione peroxidase (GPx) were measured before and after supplementation. RESULTS: The hs-CRP level decreased significantly in both the omega-۳ and CLA group (P < ۰.۰۵). IL-۶ reduced significantly in the ω-۳ group, but the reduction of IL-۶ levels in the CLA group was not significant. GPx increased in the CLA and omega-۳ groups (P < ۰.۰۵). MDA level decreased significantly in both omega-۳ and CLA groups (P < ۰.۰۵). Comparison between the groups indicates a significant change in CRP levels in the ω-۳ group relative to the control group. However, other indices did not cause any significant change in the ω-۳ and CLA groups in comparison to the control group. CONCLUSION: Diet supplementation with CLA and ω-۳ can have a beneficial effect on some indices of inflammatory and oxidative stress. Keywords: Atherosclerosis, Inflammation, Oxidative Stress, Conjugated Linoleic Acids
نویسندگان
Mohammad Hassan Eftekhari
Associate Professor, Department of Nutrition, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran
Fereshte Aliasghari
Department of Nutrition, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Ali Babaei-Beigi
Associate Professor , Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Jafar Hasanzadeh
Associate Professor, Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran