The relation between body iron store and ferritin, and coronary artery disease

سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 130

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شناسه ملی سند علمی:

JR_RYA-10-1_007

تاریخ نمایه سازی: 2 شهریور 1401

چکیده مقاله:

BACKGROUND: Iron is essential for many physiological processes; whereas, iron overload has been known as a risk factor in progression of atherosclerosis. The aim of this study was to investigate the importance of serum ferritin levels, which are known as an indicator of body iron stored in the incidence of coronary artery disease (CAD). METHODS: In a case-control study, we evaluated ۴۳۲ eligible men who underwent coronary angiography at Chamran Cardiology Hospital, Isfahan, Iran. They were separated into two groups of case (with CAD) and control (without CAD). All subjects had given written informed consents. Then, the blood samples were taken after ۱۲-۱۴ hours of fast by a biologist for measuring cardiovascular risk factors and body iron stores, including serum ferritin, serum iron, and total iron binding capacity (TIBC). For statistical analyses, chi-square test, Student’s t-test, one-way ANOVA, and the logistic regression were used. RESULTS: In the present study, ۲۱۲ participants with CAD in the case group and ۲۲۰ participants free of CAD in the control group were included in the analysis. At baseline, there were significant differences in serum ferritin (P < ۰.۰۰۱) and other cardiovascular risk factors between the two groups. Moreover, when other risk factors of CVD were included in the model, serum ferritin [Odd Ratio (OR) = ۱.۰۰۶, ۹۵% confidence interval of ۹۵% (۹۵% CI) ۱.۰۰-۱.۰۱, P = ۰.۰۴۵] and serum ferritin ≥ ۲۰۰ (OR = ۴.۴۹, ۹۵% CI ۱.۷۲-۱۱.۷۰, P < ۰.۰۰۱) were associated with CAD. CONCLUSION: High iron store, as assessed by serum ferritin, was associated with the increased risk of CAD. Furthermore, it was a strong and independent risk factor in the incident of atherosclerosis in the Iranian male population.   Keywords: Iron, Ferritin, Coronary Artery Disease, Coronary Angiography 

نویسندگان

Ali Pourmoghaddas

Associate Professor, Cardiac Rehabilitation Research Center AND Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Hamid Sanei

Associate Professor, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Mohammad Garakyaraghi

Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Fatemeh Esteki-Ghashghaei

PhD Candidate, Isfahan Neurosciences Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Maryam Gharaati

Chamran Heart Center, Isfahan University of Medical Sciences, Isfahan, Iran