Biochemical effects of oleuropein in gentamicin-induced nephrotoxicity in rats
- سال انتشار: 1395
- محل انتشار: مجله آریا آترواسکلروز، دوره: 12، شماره: 2
- کد COI اختصاصی: JR_RYA-12-2_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 228
نویسندگان
Razi Herbal Medicine Research Center AND Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Razi Herbal Medicine Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Department of Cardiology, School of Medicine, Lorestan University of Medical, Sciences, Khorramabad, Iran
Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khorramabad, Iran
Razi Herbal Medicine Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Razi Herbal Medicine Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Department of Immunology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
چکیده
BACKGROUND: Oleuropein is a natural antioxidant and scavenging free radicals. In the present study, we examined effect of oleuropein on the paraoxonase ۱ (PON۱) activity, lipid peroxidation, lipid profile, atherogenic indexes, and relationship of PON۱ activity by high-density lipoprotein-cholesterol (HDL-C) and atherogenic indices in gentamicin (GM)-induced nephrotoxicity in rats. METHODS: This is a lab trial study in Khorramabad, Lorestan province of Iran (۲۰۱۳). ۳۰ Sprague-Dawley rats were divided into three groups to receive saline; GM, ۱۰۰ mg/kg/day; and GM plus oleuropein by ۱۵ mg/kg intraperitoneal daily, respectively. After ۱۲ days, animals were anesthetized, blood samples were also collected before killing to measure the levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and very LDL (VLDL), HDL-C, atherogenic index, lipid peroxidation, and the activities of PON۱ of all groups were analyzed. Data were analyzed, and P < ۰.۰۵۰ was considered significant. RESULTS: Oleuropein significantly decreased lipid peroxidation, TG, TC, LDL, VLDL, atherogenic index, atherogenic coefficient (AC), and cardiac risk ratio (CRR). HDL-C level was significantly increased when treated with oleuropein. The activity of PON۱ in treated animals was (۶۲.۶۴ ± ۸.۶۸) that it was significantly higher than untreated animals (۴۷.۰۶ ± ۴.۱۰) (P = ۰.۰۴۷). The activity of PON۱ in the untreated nephrotoxic rats was significantly lower than that of control animals (۷۷.۸۴ ± ۹.۴۳) (P = ۰.۰۳۰). Furthermore, the activity of PON۱ correlated positively with HDL-C and negatively with AC, CRR ۱, and CRR ۲ in the treated group with oleuropein. CONCLUSION: This study showed that oleuropein improves PON۱ activity, lipid profile, and atherogenic index and can probably decrease the risk of cardiovascular death in nephrotoxic patients.کلیدواژه ها
Gentamicin, Paraoxonase ۱, Lipid Peroxidation, Nephrotoxicity, Lipid, Rat, Atherogenic Index, Oleuropeinاطلاعات بیشتر در مورد COI
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