۱۰-year risk of cardiovascular disease and body mass index in association with the obesity paradox

  • سال انتشار: 1399
  • محل انتشار: مجله آریا آترواسکلروز، دوره: 16، شماره: 1
  • کد COI اختصاصی: JR_RYA-16-1_003
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 123
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نویسندگان

Nima Motamed

Associate Professor, Department of Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Hossein Ajdarkosh

Associate Professor, Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

Majid Darkahian

Fellowship in International Cardiology, Department of Cardiology, Iran University of Medical Sciences, Tehran, Iran

Farhad Zamani

Professor, Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

Behnam Rabiee

Department of Ophtalmology, University of Illinois, Chicago, IL, USA AND Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

Amir Hossein Faraji

Assistant Professor, Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

Mehdi Nikkhah

Assistant Professor, Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

Mahmood Reza Khoonsari

Assistant Professor, Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

Mansooreh Maadi

Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

Fahimeh Safarnezhad Tameshkel

PhD Candidate, Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

Hossein Keyvani

Professor, Gastrointestinal and Liver Diseases Research Center AND Department of Virology, Iran University of Medical Sciences, Tehran, Iran

Mohammad Hadi Karbalaie Niya

Assistant Professor, Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

Behzad Farahani

Assistant Professor, Department of Cardiology, Iran University of Medical Sciences, Tehran, Iran

چکیده

BACKGROUND: Some recent studies reported an inverse association between obesity and risk of cardiovascular diseases (CVD), heart failure related mortality rate, outcomes of myocardial infarction (MI), and the consequences of cardiovascular events interventions; this inverse association was named the obesity paradox. The present study was conducted with the aim to determine whether the obesity paradox will be detectable when the ۱۰-year risk of CVD is estimated using CVD risk assessment tools.METHODS: The related data of ۲۹۱۰ subjects aged ۴۰-۷۴ years obtained in our cohort study that was carried out among ۶۱۴۰ subjects in Amol, in northern Iran, was included in this study. CVD risk assessment tools were used to estimate the ۱۰-year risk of CVD. Obesity was evaluated using ۴ indices, including waist circumference (WC), waist to height ratio (WHtR), waist to hip ratio (WHR), and body mass index (BMI). The receiver operating characteristic (ROC) curve analysis was utilized to evaluate the discriminatory power of obesity indices for ۱۰-year risk of CVD.RESULTS: Categorizing the participants to with and without obesity according to BMI showed that a significantly higher proportion of men with obesity had a ۱۰-year risk of CVD ≥ ۷.۵% and ≥ ۱۰% according to American College of Cardiology/American Heart Association (ACC/AHA) and the Framingham approaches, respectively. A higher proportion of women without obesity had a ۱۰-year risk of CVD ≥ ۷.۵% than women with obesity based on the ACC/AHA equation (۲۸.۵۴% vs. ۲۴.۱۵%; P = ۰.۰۷۰۷). BMI had a non-significant AUC (< ۰.۵) according to the the ACC/AHA equation.CONCLUSION: BMI showed a weak and non-significant inverse association with ۱۰-year risk of CVD estimated using pooled cohort equations of ACC/AHA in women. However, this result cannot directly provide enough evidence for the obesity paradox.

کلیدواژه ها

Obesity, Cardiovascular Diseases, Risk Assessment, Body Mass Index

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