The effect of calcium in water hardness on digoxin plasma levels in an experimental rat model

سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 147

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شناسه ملی سند علمی:

JR_RYA-16-5_004

تاریخ نمایه سازی: 2 شهریور 1401

چکیده مقاله:

BACKGROUND: Digoxin is a drug for ventricular rate control in atrial fibrillation (AF). The major challenge in digoxin therapy is to adjust the appropriate concentration range for this drug due to its narrow therapeutic index. Unique physiochemical properties of drinking water affect the pharmacological actions and delivery of drugs to the body whether they are administered orally, topically, or by injection. The aim of this study was to evaluate water hardness effect on digoxin therapy in an experimental rat model.METHODS: ۴۸ rats weighing ۲۰۰-۲۲۰ g were randomly assigned to three groups that received drinking water with ۵۰, ۴۰۰, and ۸۰۰ mg/l hardness degrees for ۲۸ days. Then each group was assigned into two groups. One received digoxin ۰.۲ mg/kg a day orally for four days. The other group received normal saline (as control group). Continuous recording of electrocardiogram (ECG) was performed by PowerLab system (AD Instruments Company) before and day ۴ of digoxin treatment. Then serum samples were collected and assessed for digoxin, sodium, potassium, calcium, magnesium, blood urea nitrogen (BUN), and creatinine levels.RESULTS: Water hardness in the range of ۵۰-۸۰۰ mg/l had no effect on serum digoxin levels (P > ۰.۰۵۰), but consuming hard drinking water (۴۰۰ and ۸۰۰ mg/l) could increase serum calcium levels and then cause mortality (۳۷.۵% in both groups), following changes in ECG due to digoxin consumption.CONCLUSION: Consuming hard drinking water probably interferes with digoxin pharmacodynamics in the way of toxicity induction.

نویسندگان

Shabnam Shahsavand

Assistant Professor, Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

Mohammad Moshirfar

Department of Orthopedic Surgery, Tehran University of Medical Sciences, Tehran, Iran

Seyed Hassan Seyed-Sharifi

Department of General Surgery, Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Amin Younessi-Heravi

Department of Medical Physics and Radiology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

Reza Ghasemi

Assistant Professor, Department of Cardiology, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Morteza Valaei

Department of Internal Medicine, Razavi Hospital, Imam Reza International University, Mashhad, Iran

Mohsen Yaghubi

Department of Extra-Corporeal Circulation, Razavi Hospital, Imam Reza International University, Mashhad, Iran

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