Hamidreza Roohafza - MD,
Masoumeh Sadeghi - MD,
Hamid Afshar - MD,
Ghafor Mousavi - MD,
Shahin Shirani - MD.

ABSTRACT Introduction: Several studies demonstrated association between dislipidemia and psychiatric disorder. The aim of this study is evaluation of the lipid profile of patient with comorbid generalized anxiety disorder and major depressive disorder. Method: This is a descriptive- analytic study of ۱۰۰ patient (۲۵ in major depressive disorder, ۲۵ in generalized anxiety disorder, ۲۵ in comorbid anxiety and depressive disorder and ۲۵ control subjects according to DSM-IV). Then demographic detail was filled and blood sampling for lipid profile was drowns. Beck and Kattle inventory was completed. Data were analyzed by chi-square, t-test and ANOVA. Results: Seventy-five % of patient was female. Total cholesterol, triglyceride and low-density lipoprotein cholesterol levels are significantly higher and high-density lipoprotein cholesterol level is lower in patient with comorbid anxiety and depressive disorder other groups. Discussion: According to our result, dislipdemia of comorbid anxiety and depressive disorder was considerable and lipid detection in this patient for precise prevention of atherosclerosis in first phase recommended to reduce prevalence of cardiovascular disease in these patients.   Keywords: Lipid profile, Generalized anxiety disorder, Major depressive disorder,