Kinetic and thermodynamics analysis: effect of eudragit polymer as drug release controller in electrospun nanofibers

The purpose of the present study was investigating kinetic and thermodynamic analysis using eudragit (EUD) polymer as controller to drug release mebendazole. nanofibers containing various proportions of EUD polymer, that were prepared with electrospinning technique.  In this study, the amount of drug mebendazole release was investigated using nanofibers containing EUD at concentrations ۵۰, ۲۵۰, ۵۰۰ ppm as controller at ۰ -۳۱۲ time by a Spectrophotometry (UV) method Measured.    For every Nanofiber at ۲۵ °C, ۳۱ °C, ۳۷ °C, and ۴۳ °C, drug release studies were performed for ۷۲ h. The nanofibers of EUD ۵۰۰ppm, EUD ۲۵۰ ppm and EUD ۵۰ppm had the highest resistance to drug release, respectively. The results showed that EUD plays a very good role in controlling drug release at the nanofiber. Experimental data were done fitted better with the Sahlin-Peppas model. Kinetic studies have shown that due to the hydrophilic nature of EUD, both diffusion and swelling mechanisms contribute to the drug release process. Thermodynamic analysis showed that drug release leading to increased disorder (ΔS<۰) is also an endothermic process (ΔH>۰) and at all controlling concentrations is not spontaneous (ΔG>۰). As the amount of the controller increases, activation energy increases.

کلیدواژه ها:

Drug release ، Thermodynamics ، Kinetic ، Electrospinning ، eudragit ، Mebendazole