Factors for the Primary Prevention of Breast Cancer: A Meta-Analysis of Prospective Cohort Studies

  • سال انتشار: 1400
  • محل انتشار: مجله تحقیقات در علوم سلامت، دوره: 21، شماره: 3
  • کد COI اختصاصی: JR_JRHSU-21-3_005
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 170
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نویسندگان

Jalal Poorolajal

MD, PhD, Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran- Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran- Research Center for Health Sc

Fatemeh Heidarimoghis

MSc, Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

Manoochehr Karami

PhD, Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran- Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Zahra Cheraghi

PhD, Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran- Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Fatemeh Gohari-Ensaf

MSc, Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

Fatemeh Shahbazi

MSc, Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

چکیده

Background: This report provided the effect of ۱۵ preventable factors on the risk of breast cancerincidence.Study design: A systematic review and meta-analysis.Methods: A detailed research was conducted on PubMed, Web of Science, and Scopusdatabases in January ۲۰۲۰. Reference lists were also screened. Prospective cohort studiesaddressing the associations between breast cancer and ۱۵ factors were analyzed. Between-studyheterogeneity was investigated using the χ۲, τ۲, and I۲ statistics. The probability of publication biaswas explored using the Begg and Egger tests and trim-and-fill analysis. Effect sizes were expressedas risk ratios (RRs) with ۹۵% confidence intervals (CIs) using a random-effects model.Results: Based on the results, out of ۱۴۷,۰۸۳ identified studies, ۱۹۷ were eligible, including۱۹,۴۱۳,۷۰۲ participants. The RRs (۹۵% CI) of factors associated with breast cancer were asfollows: cigarette smoking ۱.۰۷ (۱.۰۵, ۱.۰۹); alcohol drinking ۱.۱۰ (۱.۰۷, ۱.۱۲); sufficient physicalactivity ۰.۹۰ (۰.۸۶, ۰.۹۵); overweight/obesity in premenopausal ۰.۹۲ (۰.۸۲, ۱.۰۳) andpostmenopausal ۱.۱۸ (۱.۱۳, ۱.۲۴); nulliparity ۱.۱۶ (۱.۰۳, ۱.۳۱); late pregnancy ۱.۳۷ (۱.۲۵, ۱.۵۰);breastfeeding ۰.۸۷ (۰.۸۱, ۰.۹۳); ever using oral contraceptive ۱.۰۰ (۰.۹۶, ۱.۰۵); ever using estrogen۱.۱۳ (۱.۰۴, ۱.۲۳); ever using progesterone ۱.۰۲ (۰.۸۴, ۱.۲۴); ever using estrogen/progesterone ۱.۶۰(۱.۴۲, ۱.۸۰); ever taking hormone replacement therapy ۱.۲۶ (۱.۲۰, ۱.۳۲); red meat consumption۱.۰۵ (۱.۰۰, ۱.۱۱); fruit/vegetable consumption ۰.۸۷ (۰.۸۳, ۰.۹۰); and history of radiation therapy,based on single study ۱.۳۱ (۰.۸۷, ۱.۹۸).Conclusions: This meta-analysis provided a clear picture of several factors associated with thedevelopment of breast cancer. Moreover, the useful information in this study may be utilized forranking and prioritizing preventable risk factors to implement effective prevention programs.

کلیدواژه ها

Breast neoplasms, Risk factors, Behavior, Nutrition, Meta-analysis

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