Preparation of bioactive polymer-based composite by different techniques and application in tissue engineering: A review

Tissue engineering (TE) employs biological, chemical, and engineering methods to regenerate and restore injuredor lost living tissues by applying biologically activated biomaterials, cells, and molecules. The fast and convenientrestoration of tissue is a great challenge, emphasizing the need to imitate tissue structure and its physicochemical,biological, and mechanical behavior to give back the desired functionality of damaged tissue. Depending onthe particular tissue, numerous requirements have to be fulfilled with the help of material and scaffold designthat provides a base for cell adhesion and proliferation. As a result, countless biodegradable and bioresorbablematerials have been extensively examined. Composite systems combine the benefits of bioactive ceramics andpolymers, which seem to be good alternatives for bone tissue engineering. This article intends to introduce bioactivepolymer, tissue engineering methods, the kinds of biomaterials applied in scaffold invention, and the differentapproaches to producing the bioactive polymer-based composites with various structures such as porous, membrane,and ۳D structure. Biomaterials and invention techniques could crucially influence the consequences of thescaffold's design architectures, cell proliferation, and mechanical behavior. Moreover, an excellent scaffold assistscell generation and the provision of cell nutrients in the human body with their particular material characteristics.

کلیدواژه ها:

Scaffold ، Tissue engineering ، Biodegradable ، Bioresorbable polymer-based composites ، Activated biomaterials ، Bioactive polymer-based composite