Study of the Effect of Concurrent Therapy of Spironolactone With Levodopa on Depression Disorder in Male Rats

سال انتشار: 1400
محل انتشار: مجله تحقیقات دارویی ابن سینا، دوره: 2، شماره: 1
کد COI اختصاصی: JR_AJPR-2-1_002
زبان مقاله: انگلیسی
تعداد مشاهده: 232

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نویسندگان

Mahdi Heidari Soureshjani

Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences,Hamadan, Iran

Rasool Haddadi

Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences,Hamadan, Iran

Amir Nili

Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences,Hamadan, Iran

Amir Larki

Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences,Hamadan, Iran

چکیده

Background: Depression has a high prevalence and high mortality and a tremendous negative impact onpeople’s quality of life. This study was considered to examine the effect of levodopa and spironolactone(SPIR) in ۶-hydroxydopamine (۶-OHDA)-induced depression-like behavior.Methods: Parkinson was induced by the unilateral intra-nigral injection of ۶-OHDA (۸ μg/۲ μL/rat) inthe central region of the substantia nigra pars compacta (SNc). In the levodopa treatment group, ۲۱days after the injection of ۶-OHDA, the rats were treated with (i.p.) injections of levodopa (۱۵ mg/kg)for ۱۴ consecutive days. In the other group, only SPIR (۲۵ mg/kg) was added to levodopa (۱۵ mg/kg) asa concurrent therapy according to the treatment protocol. Anxiety and depression-like behavior wereassessed by behavioral tests such as passive avoidance task (PAT), open field test (OFT), tail suspensiontest (TST), and forced swimming test (FST).Results: Intra-nigral injection of ۶-OHDA in the SNc increased anxiety and depression-like behavior.Our results showed that the use of levodopa (۱۵ mg/kg) treatment significantly attenuated depressionlikebehavior induced by ۶-OHDA in FST (P < ۰.۰۰۱) and TST (P < ۰.۰۰۱) in rats. Moreover, levodopa (۱۵mg/kg) + SPIR (۲۵ mg/kg) significantly reduced the symptoms of depression-like behavior induced by۶-OHDA in OFT (P < ۰.۰۵), FST (P < ۰.۰۰۱), and TST (P < ۰.۰۰۱) tests in rats.Conclusion: Based on the findings, the intra-nigral injection of ۶-OHDA into rats could cause anxietyand depression-like behavior in the fourth week onwards. Treatment with levodopa was able to attenuatestress and depressive symptoms. Additionally, our results revealed that SPIR could improve the effect oflevodopa on depression-like behavior. Base on the results of this study, it is suggested that levodopa andSPIR could have some improving effects on ۶-OHDA-induced depression-like behavior in parkinsonianrats.

کلیدواژه ها

Depression, Parkinson’s disease, ۶-OHDA

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