Early Hepatic Complications during the First Year after Bone Marrow Transplantation in Patients with Leukemia

Introduction and Aims: Bone marrow transplantation (BMT) is a treatment in patients with leukemia. Liver dysfunction is a common problem in BMT recipients that can have a direct effect on the final results. Therefore, it is important to determine the etiology and its incidence for appropriate treatment. The aim of this study was to determine the prevalence of liver dysfunction and its causes after BMT in patients with leukemia.Materials and Methods:: One hundred and twenty leukemia patients were transplanted at the bone marrow transplant center of Imam Reza Hospital in Kermanshah. ۶۷.۵% were male and ۳۲.۵% were female. Mean age of patients was ۴۷.۷± ۱۳. ۱۳.۳۸ years. All patients underwent sonography before and after transplantation. Hepatic enzymes, Blood indexes and seroepidemiology of HIV, HBs, and CMV were measured. Patients were given prophylaxis with Ursodiol (۳۰۰ mg/kg) and N-acetylcysteine (۱۵۰ mg/kg).Results: Abnormal total bilirubin, hepatic GVHD, and high ferritin were reported in ۷.۵%, ۱۵%, and ۷۱% of patients, respectively. IgG-Anti CMV, HBsAg and HIV were reported ۵۶%, ۱.۶% and ۰.۸%, respectively. Ast, Alt, and Alph were reported abnormal in ۵%, ۲۰%, and ۱۵% of subjects, respectively. Liver sonography was negative for VOD (Veno-Occlusive disease). The incidence of mortality was ۶%.Conclusion: Although liver disorders were observed following GVHD and the presence of viruses, but no case of VOD was shown. Prophylaxis with Ursodiol and N-acetylcysteine seems to be successful in these patients.

کلیدواژه ها:

Veno-Occlusive Disease (VOD) ، bone marrow transplant ، liver disorders