Evaluation of Nifedipine Administration on Embryo Transfer Success Rate: a Randomized Clinical Trial
- سال انتشار: 1401
- محل انتشار: مجله علمی پژوهشی دانشگاه علوم پزشکی زنجان، دوره: 30، شماره: 141
- کد COI اختصاصی: JR_ZUMS-30-141_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 182
نویسندگان
Dept. of Obstetrics and Gynecology, Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran
Dept. of Cardiology, Tehran University of Medical Sciences, Tehran Heart Center, Tehran, Iran
Dept. of Obstetrics and Gynecology, Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran
Dept. of Obstetrics and Gynecology, Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran
چکیده
Background and Objective: In- vitro fertilization (IVF) is one of the approved treatment options for infertility. Despite many progresses in this field, its success rate is about ۲۰ -۲۵%. Utilization of drugs which suppress or decrease uterine smooth muscle contraction before embryo transfer, theoretically can improve fertility by increasing implantation rate. This study was designed to evaluate nifedipine administration on embryo transfer success. Materials and Methods: In this double blinded randomized clinical trial, ninety-eight infertile women from primary and secondary causes were included in two groups; one group received placebo and the other group a single dose of ۲۰ mg nifedipine, both thirty minutes before embryo transfer. Primary outcome was defined as clinical pregnancy, and secondary outcomes as live birth, ectopic pregnancy, multiple gestation and abortion. Results: Clinical pregnancy occurred in eighteen patients in the placebo group and in seventeen patients in nifedipine group (OR = ۰.۹۱, ۰.۴۰-۲.۰۹ (۹۵% CI)). Sixteen patients in placebo group and fourteen patients in nifedipine group had successful live births (OR = ۰.۸۲, ۰.۳۴-۱.۹۵ (۹۵% CI)). Multiple gestation (OR = ۱.۷۱, ۰.۲۴- ۱۱.۷۸ (۹۵% CI)) and abortion (OR = ۰.۴۶, ۰.۰۷-۲.۹۵ (۹۵% CI)) were not different between the two groups. No side effect of drug occurred in any group. Conclusion: A single dose of ۲۰ mg nifedipine tablet administered thirty minutes before IVF had no effect on improving clinical pregnancy and live birth rate. Using higher doses, or different regimens in specific patients’ subgroups may have more effect on embryo transfer success.کلیدواژه ها
In vitro fertilization, Infertility, Nifedipineاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.