Determination of Fuconazole Using Flow Injection Analysis and Turbidity Measurement by a Homemade NAG-۴SX۳-۳D Analyzer

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 137

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شناسه ملی سند علمی:

JR_CHM-6-10_002

تاریخ نمایه سازی: 11 مرداد 1401

چکیده مقاله:

The research work exemplifies a sensitive, rapid, and simple procedure for measuring fluconazole using turbidity-continuous flow injection analysis for the generation of white precipitate via the reaction of fluconazole with phosphotungestic acid, and detecting the attenuation of incident light caused by light colliding with the precipitate surface grain using the NAG-۴SX۳-۳D analyzer to determine turbidity (۰-۱۸۰ ͦ). The linear range extended from ۰.۰۱-۱۸ mmol.L-۱ for fluconazole measurements were considerably lower than ۰.۵ RSD % for the repetition (n=۶) for the concentration chosen (۲, ۱۳ mmol.L-۱), with limit of detection=۷.۵۳۴۲ ng/sample from the gradual dilution over the lowest concentration on the calibration graph , linear dynamic range (r = ۰.۹۹۸۹), (correlation coefficient), percentage linearity (R۲ percent = ۹۹.۷۹) traditional approaches (UV-spectrophotometric at λmax=۲۶۰ nm with linear range (۰.۰۰۱-۱) mmol.L-۱, r=۰.۹۹۸۷, R۲=۰.۹۹۷۳, R۲%=۹۹.۷۳, and turbidimetric method with linear range (۰.۰۱-۱۷) mmol.L-۱ , r= ۰.۹۸۶۹, R۲=۰.۹۷۴۰,  R۲%= ۹۷.۴۰ were compared with the suggested strategy. In comparison to the typical reference method's ۱۰ mm irradiation, it was discovered, in addition to the technique's developed sensitivity and the use of minimal chemicals, that this approach is characterized by a dynamic system, which avoids precipitated particle setting during measurements. The results indicated that the developed method has a wide range of concentration with a high linearity and sensitivity. Furthermore, the continuous dilution in CFIA allows for the management of high or low concentrations, for a wider range of applications. The devised approach is believed to be the most acceptable for fluconazole molecule determination in pure and pharmaceutical formulations when compared with the reference methods. The method used in this research work is a pioneered developed approach and proved its success in determination of fluconazole in pure and pharmaceutical formulations. 

نویسندگان

Nagham Shakir Turkie

Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq

Sarah Faris Hameed

Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq

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