Study of Anti-nociceptive Role of the Manna of Hedysarum and the Neurotransmitter Systems Involved in Mice
- سال انتشار: 1401
- محل انتشار: فصلنامه طب دامی ایران، دوره: 16، شماره: 3
- کد COI اختصاصی: JR_IJVM-16-3_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 187
نویسندگان
Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
Department of Clinical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Department of Physiology Faculty of Veterinary Medicine Science and Research Branch Islamic Azad University,Tehran,Iran
Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
BACKGROUND: Pain is an unpleasant experience that serves as a survival mechanism and is mediated via the central and peripheral nervous systems. Manna of hedysarum, also called Persian Manna or Taranjebin, is known to have medical properties in Persian traditional medicine. OBJECTIVES: The main purpose of the current paper is to determine the possible antinociceptive effect of Manna of hedysarum as well as the neurotransmitter systems involved, in mice. METHODS: The first experiment was designed to reveal the effective dose of Manna of hedysarum. Adult male albino mice were injected with Manna of Hedysarum (۱۰۰, ۲۰۰, and ۴۰۰ mg/kg) Ethanolic Extract (MHEE) or morphine (۵ mg/kg). In experiment ۲, MHEE (۴۰۰ mg/kg), naloxone (۲ mg/kg), and MHEE (۴۰۰ mg/kg) plus naloxone (۲ mg/kg) were injected. Experiments ۳-۵ were similar to experiment ۲, except that naloxone was replaced with L-NG-Nitro Arginine Methyl Ester (۱۰ mg/kg), cimetidine (۱۲.۵ mg/kg), and cyproheptadine (۴ mg/kg). Then the formalin test was performed, and the paw licking time was measured. RESULTS: Based on the findings, MHEE reduced the pain response in a dose-dependent manner (P< ۰.۰۵). The co-injections of MHEE with mentioned antagonists significantly decreased the antinociceptive effect of MHEE on the licking and biting time of the injected paw (P< ۰.۰۵). CONCLUSIONS: These findings suggest that MHEE has an antinociceptive effect in mice and possibly acts on opioidergic, nitrergic, histaminergic and serotonergic systemsکلیدواژه ها
Anti-nociceptive, Histaminergic, Manna of hedysarum, mice, Nitrergic, Opioidergic, Sero-tonergic systemاطلاعات بیشتر در مورد COI
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