Novel chitosan-quinic acid nanoparticles labeled with m۹۹ technetium for breast cancer imaging
- سال انتشار: 1401
- محل انتشار: مجله علوم نانو، دوره: 9، شماره: 3
- کد COI اختصاصی: JR_NAMJ-9-3_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 164
نویسندگان
Faculty of Pharmacy, Islamic Azad University, Tehran, Iran
Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Faculty of Pharmacy, Islamic Azad University, Tehran, Iran
Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Pasteur Institute of Iran
Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Pasteur Institute of Iran
Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Objective(s): Today, cancer is one of the health concerns in modern societies. The use of nanoparticles in medical science has created new possibilities for diagnosis, imaging of tumors, and treatment of cancer in humans. Materials and Methods: In this study, chitosan nanoparticles modified with quinic acid were used to diagnose breast cancer using a single-photon emission computed tomography imaging technique. For this purpose, quinic acid was activated by EDC/NHS and then binding was performed by adding chitosan nanoparticles. Results: TEM, DLS, FTIR, and LC/MASS analyzes were used to investigate this conjugation. MTT toxicity test showed no toxicity on the HEK-۲۹۳ cell lines and therapeutic properties for the MCF-۷ cell line. The response surface method depends on the central composite design that was applied. For the highest labeling efficiency, using ۳ factors: the amount of chitosan-quinic acid, pH, and SnCl۲ as a reducing agent, and the efficiency of labeling was evaluated by thin-layer chromatography (TLC). Conclusion: Finally, the study of biodistribution using SPECT imaging in cancer mice and its comparison with blocking tests showed that this compound has a good ability to diagnose breast cancer.کلیدواژه ها
Blocking, Breast Cancer, Chitosan, Quinic acid, SPECT imagingاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.