The Design of Soft Drugs: Basic Principles, Energetic Metabolite Methods, Approved Compounds, and Pharmaceutical Applications

  • سال انتشار: 1401
  • محل انتشار: فصلنامه مروری شیمی، دوره: 4، شماره: 3
  • کد COI اختصاصی: JR_JCHM-4-3_003
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 153
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نویسندگان

Babafakruddin Peddagundam

Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, K. R. Palli Cross, Ananthapuramu-۵۱۵۷۲۱, Andhra Pradesh, India

Hindustan Abdul Ahad

Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, K. R. Palli Cross, Ananthapuramu-۵۱۵۷۲۱, Andhra Pradesh, India

Haranath Chinthaginjala

Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, K. R. Palli Cross, Ananthapuramu-۵۱۵۷۲۱, Andhra Pradesh, India

Tarun Ksheerasagare

Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, K. R. Palli Cross, Ananthapuramu-۵۱۵۷۲۱, Andhra Pradesh, India

Aravind Kumar Ganthala

Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, K. R. Palli Cross, Ananthapuramu-۵۱۵۷۲۱, Andhra Pradesh, India

Govardhan Reddy Gummadisani

Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, K. R. Palli Cross, Ananthapuramu-۵۱۵۷۲۱, Andhra Pradesh, India

چکیده

This work explores soft drugs and their configuration for drug delivery. Compared with the stimulated soft compound, soft drugs have a fast metabolism and exert their therapeutic effects. They are organically active drugs, carefully formulated to have a predictable and controllable absorption near harmless compared with sedentary products. The broader neurometabolic drug plan concept depends on the soft drug configuration. This is usually accomplished by using close analogues of proven lead compounds and an ester as a metabolically delicate weakness. A rationally designed or accidentally developed soft drug has proven clinically useful. The idea of neurometabolic drug plans relies upon the configuration of soft drugs. This method is immensely flexible and can be implemented to create inventive, new substances in a widespread helpful field. A metabolically, especially hydrolytically labile moiety, is attached to the construction to control and direct digestion.

کلیدواژه ها

Antidrug, Drug, Metabolism, Soft drug, Therapeutic index

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