Effect of MK-۸۰۱, an antagonist of NMDA receptor in the pedunculopontine tegmental nucleus, on cardiovascular parameters in normotensive and hydralazine hypotensive rats

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 164

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شناسه ملی سند علمی:

JR_IJBMS-25-5_004

تاریخ نمایه سازی: 21 خرداد 1401

چکیده مقاله:

Objective(s): In the present study, the cardiovascular effects of glutamate NMDA receptor of the pedunculopontine tegmental nucleus (PPT) in normotensive and hydralazine (HLZ) hypotensive rats were evaluated. Materials and Methods: In the normotensive condition, MK-۸۰۱(۱ nmol; an NMDA receptor antagonist) and L-glutamate (L-Glu, ۵۰ nmol an agonist) alone and together were microinjected into the nucleus using a stereotaxic device. In hypotensive condition, ۲ min after induction of hypotension by HLZ (۱۰ mg/kg, intravenous), drugs, same as in normotensive condition, were microinjected into the PPT. Recorded mean arterial pressure (MAP), systolic blood pressure (SBP), and heart rate (HR) were recorded throughout the experiment by a Power lab apparatus that was connected to a catheter inserted into the femoral arty. The cardiovascular changes (Δ) induced by microinjection drugs were computed and statistically analyzed.Results: In the normotensive condition, L-Glu significantly increased ΔMAP and ΔSBP (P<۰.۰۰۱) and decreased ΔHR (P<۰.۰۱) compared with the control. MK-۸۰۱ alone significantly increased HR (P<۰.۰۵) while co-injected with L-Glu + MK-۸۰۱ it significantly attenuated the L-Glu effect on ΔMAP and ΔSBP but augmented ΔHR (P<۰.۰۱). In the hydralazine hypotension condition, L-Glu significantly improved hypotension (P<۰.۰۱) and deteriorated bradycardia induced by HLZ (P<۰.۰۵). MK-۸۰۱ alone did not significantly affect ΔMAP, ΔSBP, and ΔHR but when co-injected with L-Glu (L-Glu + MK-۸۰۱) it could significantly attenuate the cardiovascular effect of L-Glu in the PPT. Conclusion: We found that activation of NMDA receptors of the glutamatergic system in the PPT evoked blood pressure and inhibited HR in both normotensive and hypotensive conditions in rats. 

نویسندگان

Mohammad Reza Hosseiniravesh

Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

Vida Hojati

Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

Abolfazl Khajavirad

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Hooman Shajiee

Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

Mohammad Naser Shafei

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Reza Mohebbati

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

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  • Martinez-Gonzalez C, Bolam JP, Mena-Segovia J. Topographical organization of the ...
  • Mena-Segovia J, Bolam JP, Magill PJ. Pedunculopontine nucleus and basal ...
  • Alam M, Schwabe K, Krauss JK. The pedunculopontine nucleus area: ...
  • Garcia-Rill E, Simon C, Smith K, Kezunovic N, Hyde J. ...
  • Jenkinson N, Nandi D, Muthusamy K, Ray NJ, Gregory R, ...
  • Kang Y, Kitai S. Electrophysiological properties of pedunculopontine neurons and ...
  • Winn P. How best to consider the structure and function ...
  • Garcia-Rill E. The pedunculopontine nucleus. Prog Neurobiol. ۱۹۹۱;۳۶:۳۶۳-۳۸۹ ...
  • Garcia-Rill E, Saper C, Rye DB, Kofler M, Nonnekes J, ...
  • Kroeger D, Ferrari LL, Petit G, Mahoney CE, Fuller PM, ...
  • Pahapill PA, Lozano AM. The pedunculopontine nucleus and Parkinson’s disease. ...
  • Padley JR, Kumar NN, Li Q, Nguyen TB, Pilowsky PM, ...
  • Dampney RA. Central neural control of the cardiovascular system: Current ...
  • Topchiy I, Waxman J, Radulovacki M, Carley DW. Functional topography ...
  • Shafei MN, Nikyar T, Hosseini M, Niazmand S, Paseban M. ...
  • Shafei MN, Niazmand S, Hosseini M, Daloee MH. Pharmacological study ...
  • Pasandi H, Abbaspoor S, Shafei MN, Hosseini M, Khajavirad A. ...
  • Reiner A, Levitz J. Glutamatergic signaling in the central nervous ...
  • Meldrum BS. Glutamate as a neurotransmitter in the brain: review ...
  • Basting T, Xu J, Mukerjee S, Epling J, Fuchs R, ...
  • Pyatin V, Tatarnikov V. NMDA receptors of A۵ area in ...
  • Maione S, Berrino L, Vitagliano S, Leyva J, Rossi F. ...
  • Nasimi A, Shafei M, Alaei H. Glutamate injection into the ...
  • Alikhani V, Mohebbati R, Hosseini M, Khajavirad A, Shafei MN. ...
  • Mohebbati R, Hosseini M, Khazaei M, Rad AK, Shafei MN. ...
  • Nikyar T, Hosseini M, Niazmand S, Shafei MN. Evaluation of ...
  • Paxinos G. Rat Brain: In Stereotaxic Crdinats ۲eppr: Academic press; ...
  • Martin DS, Haywood JR. Sympathetic nervous system activation by glutamate ...
  • Zhang X-J, Xu M-Y, Lv N. Influence of glutamate and ...
  • Curtis KS, Cunningham JT, Heesch CMJAJoP-R, Integrative, Physiology C. Fos ...
  • Busnardo C, Crestani CC, Tavares RF, Resstel LB, Correa FM. ...
  • Mori F, Okada K-i, Nomura T, Kobayashi Y. The pedunculopontine ...
  • Hamani C, Aziz T, Bloem BR, Brown P, Chabardes S, ...
  • Yasui Y, Cechetto DF, Saper CB. Evidence for a cholinergic ...
  • Takakusaki K, Shiroyama T, Yamamoto T, Kitai S. Cholinergic and ...
  • Ford B, Holmes CJ, Mainville L, Jones BE. GABAergic neurons ...
  • Bohus B, Koolhaas JM, Korte SM, Roozendaal B, Wiersma A. ...
  • Verberne A. Cuneiform nucleus stimulation produces activation of medullary sympathoexcitatory ...
  • Steininger TL, Rye DB, Wainer BH. Afferent projections to the ...
  • Mena‐Segovia J, Sims HM, Magill PJ, Bolam JP. Cholinergic brainstem ...
  • Karlsson GA, Preuss CV, Chaitoff KA, Maher TJ, Ally A. ...
  • Urban M, Gebhart G. Central mechanisms in pain. Med Clin ...
  • Carlson JD, Iacono RP, Maeda G. Nociceptive excited and inhibited ...
  • Benarroch EE. Pedunculopontine nucleus: Functional organization and clinical implications. Neurology ...
  • Sacco M, Meschi M, Regolisti G, Detrenis S, Bianchi L, ...
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