Effect of Probiotics in Prevention of Neonatal Jaundice
- سال انتشار: 1401
- محل انتشار: مجله علمی ناباروری ایران، دوره: 13، شماره: 2
- کد COI اختصاصی: JR_IRJN-13-2_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 214
نویسندگان
Robabeh Mousavinejad Chenarani
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Neonatal Research Center, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Clinical Research Development Center, Mashhad University of Medical Sciences, Mashhad, Iran
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Jaundice is the most common problem among neonates. Although neonatal jaundice is highly prevalent in Iran and the prevention and treatment of this disease is incredibly important, few studies have been conducted on the effect of probiotics in the prevention of hyperbilirubinemia in Iran so far. Considering the contradictory results in this regard, this study was conducted to investigate the effect of probiotics in preventing jaundice among neonates. Methods: The statistical population of this three-blinded clinical trial on the first of January ۲۰۲۱ consisted of ۱۹۶ neonates who were divided into two groups of placebo and intervention. The neonates with a gestational age of more than ۳۷ weeks, birth weight of more than ۲,۵۰۰ grams, and without risk factors for jaundice were included in the study after that the research objectives and procedures were explained to their parents and their informed consent was obtained. Patients were randomly divided into the intervention and placebo groups. The intervention group underwent treatment with probiotics (۱۰۱۰ Saccharomyces boulardii daily for ۵ days), while the other group received treatment with a placebo. The level of bilirubin was measured with a skin bilirubin meter and, if necessary (i.e., bilirubin more than ۱۵), a blood test was administered before the intervention and on the third and fifth days after the intervention. The effect of probiotics on jaundice was compared in the two groups. Results: Based on the study results, the level of forehead and chest bilirubin was not significantly different between the study groups before the intervention and ۳ and ۵ days after the intervention (P> ۰.۰۵). In cases that skin bilirubin levels were higher than ۱۵ on the fifth day ,the mean serum bilirubin level was obtained at ۱۵.۷۱±۰.۹۹ mg/dl and ۱۷.۴۲±۱.۱۷ mg/dl in the intervention and placebo group, respectively, which was statistically significant (P = ۰.۰۳). Conclusion The results of this study showed that the use of Saccharomyces boulardi decreased the level of serum bilirubin (P=۰.۰۳).کلیدواژه ها
Jaundice, neonate, Probiotic, Saccharomyces boulardiiاطلاعات بیشتر در مورد COI
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