Salivary Streptococcus mutans and Lactobacilli Levels as Indicators of Dental Caries Development in Iranian Patients with Systemic Sclerosis
- سال انتشار: 1401
- محل انتشار: فصلنامه میکروب شناسی پزشکی ایران، دوره: 16، شماره: 4
- کد COI اختصاصی: JR_IJMM-16-4_009
- زبان مقاله: انگلیسی
- تعداد مشاهده: 206
نویسندگان
Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Medical Microbiology, Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Bacteriology and Virology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background and Objective: Systemic sclerosis is an autoimmune disorder with orofacial manifestations, including tooth decay. Lactobacilli can inhibit biofilm formation and growth of cariogenic pathogens, such as Streptococcus mutans. We aimed to assess the salivary levels of S. mutans and Lactobacilli as indicators of dental caries development in patients with systemic sclerosis. Methods: In this cross-sectional study, ۸۰ patients with systemic sclerosis were assigned into ۲ groups, anti-centromere antibody (ACA) positive (n=۴۲) and ACA-negative (n=۳۸). Besides, ۸۰ age- and gender-matched healthy individuals were enrolled as control. Unstimulated saliva was collected in sterile tubes. Blood agar and tomato juice agar were used to cultivate S. mutans and Lactobacilli. The number of colony-forming units per milliliter (CFU/mL) was calculated and compared between the groups. Results: S. mutans in patients (median=۱.۶×۱۰۷ CFU/mL; interquartile range (IQR): ۱.۱–۳.۱ ×۱۰۷ CFU/mL) was significantly higher than control group (median=۵.۱×۱۰۶ CFU/mL; IQR: ۵.۱–۷.۹ ×۱۰۶ CFU/mL) (P< ۰.۰۰۰۱, Mann-Whitney U-test); however, the median Lactobacilli levels was similar between these groups (۳.۴×۱۰۶ vs. ۲.۲×۱۰۶ CFU/mL; P=۰.۰۹۵). The median concentrations of S. mutans (۱.۳×۱۰۷ vs. ۲.۴×۱۰۷ CFU/mL; P=۰.۳۴۲) and Lactobacilli (۴.۱×۱۰۶ CFU/mL vs. ۳.۱×۱۰۶ CFU/mL; P=۰.۵۱۵) in the ACA-positive and ACA-negative patients had no significant differences. There were no significant correlation coefficients between S. mutans and Lactobacilli levels in the study groups (P> ۰.۰۵). Conclusion: Our findings suggest the higher levels of salivary S. mutans in patients with systemic sclerosis might increase the likelihood of dental caries over time; however, it was not affected by the ACA status.کلیدواژه ها
Lactobacilli, Saliva, Streptococcus mutans, Systemic sclerosis, لاکتوباسیل ها, بزاق, استرپتوکوکوس موتانس, اسکلروز سیستمیکاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.