Nanostructured lipid carriers loaded with Melaleuca alternifolia Oil preparation, physicochemical assessment, and evaluation of antimicrobial effects against Staphylococcus epidermidis
محل انتشار: مجله بین المللی ابعاد نانو، دوره: 12، شماره: 1
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 174
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شناسه ملی سند علمی:
JR_IJND-12-1_006
تاریخ نمایه سازی: 10 خرداد 1401
چکیده مقاله:
Thanks to their outstanding advantages, nanostructured lipid carriers (NLCs) have recognized in various fields these days. One way to discover extra useful products against typical bacteria (e.g., Staphylococcus epidermidis) is NLCs loaded with essential oils. This paper aims to provide NLCs to encapsulate MA oil and characterize and survey the obtained MA oil-loaded NLCs on S. ep < /em> Thanks to their outstanding advantages, nanostructured lipid carriers (NLCs) have recognized in various fields these days. One way to discover extra useful products against typical bacteria (e.g., Staphylococcus epidermidis) is NLCs loaded with essential oils. This paper aims to provide NLCs to encapsulate MA oil, characterize, and survey the obtained MA oil-loaded NLCs on S. epidermidis. The combination has provided using the hot melt homogenization technique. Afterward, the particle size distribution (PSD) (particle size analyzer), morphology (SEM), zeta potential (surface charge of NLCs), and the stability (the effect of acidity) of the prepared NLCs were analyzed. This has followed by estimating the MIC of MA oil-loaded NLCs and comparing carriers and oil emulsion of MA against S. epidermidis. MA oil-loaded NLCs are spherical NPs with a mean size of ۱۰۴.۵ nm and narrow size distribution (PDI=۰.۲۲). The antibacterial evaluation results demonstrated that MA oil-loaded NLCs had a higher in vitro antimicrobial activity compared to the oil emulsion of MA. Consequently, NLCs could be a suitable carrier to enhance new antimicrobial agents. idermidis. The combination has provided using the hot melt homogenization technique. Afterward, the particle size distribution (PSD) (particle size analyzer), morphology (SEM), zeta potential (surface charge of NLCs), and the stability (the effect of acidity) of the prepared NLCs were analyzed. This has followed by estimating the MIC of MA oil-loaded NLCs and comparing carriers and oil emulsion of MA against S. epidermidis. MA oil-loaded NLCs are spherical NPs with a mean size of ۱۰۴.۵ nm and narrow size distribution (PDI=۰.۲۲). The antibacterial evaluation results demonstrated that MA oil-loaded NLCs had a higher in vitro antimicrobial activity compared to the oil emulsion of MA. Consequently, NLCs could be a suitable carrier to enhance new antimicrobial agents.
کلیدواژه ها:
Antimicrobial Activity ، Melaleuca Alternifolia Oil ، Nanostructured Lipid Carriers ، Scanning Electron Microscope (SEM) ، Staphylococcus epidermidis
نویسندگان
Farzaneh Lotfipour
Food & Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hamed Hamishehkar
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Maryam Mohammadi
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Shahriar Shahi
Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Sara Salatin
Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Aziz Eftekhari
Maragheh University of Medical Sciences, Maragheh, Iran.
Solmaz Maleki Dizaj
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
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