Extremely low frequency electromagnetic fields alter expression of C-Myc in gastric cancer cell line

  • سال انتشار: 1400
  • محل انتشار: اولین کنگره ملی رویکردهای نوآورانه در سیستم بیولوژی، داروسازی وصنایع غذایی
  • کد COI اختصاصی: SBPFST01_034
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 235
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نویسندگان

Fereshteh Mansoury

Department of Cell Biology and Genetics, Bushehr Branch, Islamic Azad University, Bushehr, Iran.

Soheila Abdi

Department of Physics, Safadasht Branch, Islamic Azad University, Tehran, Iran

Nahid Babaei

Department of Cell Biology and Genetics, Bushehr Branch, Islamic Azad University, Bushehr, Iran

Maliheh Entezari

Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

Abbas Doosti

Biotechnology Research Center, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

چکیده

Biological effects of electromagnetic fields (EMF), in particular their beneficial or adverse effects on the promotion and progression of cancer, have attracted considerable attention. C-Myc has an important regulatory role in cell transformation and causes metabolic changes that accompany malignant transformation. In this study, changes in the expression of c-Myc in the gastric cancer cell line (AGS) following the exposure to extremely low-frequency magnetic fields (ELF-MF) were investigated. AGS cells were exposed to ELF-MF with magnetic flux densities of ۰. ۲۵, ۰.۵, ۱, and ۲ mT for ۱۸ h, discontinuously (۲h on/ ۲h off). To evaluate the expression changes of c-Myc real-time PCR was used. The results showed that discontinuous magnetic fields could reduce c-Myc expression. The difference in the results of c-Myc under the influence of magnetic fields may be described by the hypothesis of the window effect of the fields. Our results indicated that ELF-MFs can induce changes in c-Myc expression

کلیدواژه ها

Adenocarcinoma gastric cell line (AGS); electromagnetic field; C-Myc

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