The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study

  • سال انتشار: 1401
  • محل انتشار: International Journal of Reproductive BioMedicine، دوره: 20، شماره: 4
  • کد COI اختصاصی: JR_IJRM-20-4_008
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 330
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نویسندگان

Leila Maghsoumi-Norouzabad

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Maryam Labibzadeh

Center of Therapy and Research Infertility Jahad Daneshgahi, Ahvaz, Iran.

Ahmad Zare Javid

Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Seyed Ahmad Hosseini

Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Gholam Abbas Kaydani

Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Maryam Dastoorpur

Department of Biostatistics and Epidemiology, Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

چکیده

 Background: The prevalence of vitamin D deficiency and male infertility is high in Iran. Objective: The present research aimed to examine the association between serum vitamin D [۲۵(OH)D], parameters of semen including semen volume, sperm count, motility and morphology, and reproductive hormones in infertile Iranian men. Materials and Methods: This was a cross-sectional study on ۱۱۹ infertile men conducted between September ۲۰۱۸ and May ۲۰۱۹. Subjects were divided into ۳ groups based on serum vitamin D levels: deficient (< ۱۰ ng/mL), insufficient (۱۰ ng/mL ≤ ۲۵(OH)D ≤ ۳۰ ng/mL), and sufficient (> ۳۰ ng/mL). Body mass index and waist circumference were measured. ۲۵(OH)D, testosterone, sex hormone-binding globulin, luteinizing hormone (LH), follicle-stimulating hormone and estradiol levels, and semen parameters were assessed. Results: The semen volume, sperm counts, total and progressively motile sperm, normal sperm morphology, testosterone levels, and testosterone/estradiol ratio were substantially higher in the sufficient group compared to the other groups (p < ۰.۰۰۱). Also, in the sufficient group, serum LH (p < ۰.۰۰۱) and estradiol (p < ۰.۰۰۱, p = ۰.۰۱) were notably lower and serum sex hormone-binding globulin (p < ۰.۰۰۱) and the testosterone/LH ratio (p < ۰.۰۰۱) were considerably higher compared to the insufficient and deficient groups. Conclusion: Our study showed a positive relationship between serum vitamin D levels, and seminal parameters and sex hormones in Iranian infertile males.

کلیدواژه ها

Infertility, Male, Vitamin D, Semen analysis, Gonadal hormones, Pituitary hormones., ناباروری, مردان, ویتامین D, آنالیز مایع منی, هورمون­های غدد جنسی, هورمون­های هیپوفیز.

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