The Correlation of PT-INR and D-dimer negation time under Warfarin therapy in Patients with venous thromboembolism

  • سال انتشار: 1400
  • محل انتشار: هشتمین کنفرانس بین المللی بهداشت،درمان و ارتقای سلامت
  • کد COI اختصاصی: HWCONF08_011
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 122
دانلود فایل این مقاله

نویسندگان

Mohammad Reza Pashaei

Department of internal medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia-Iran

چکیده

Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PTE), which requires long-term hospitalization and clinical care. The diagnostic laboratory marker D-dimer for VTE and the International Normalized Prothrombin Time Ratio (PT-INR) is a measure used to assess the function of coagulation factors in patients. This study aimed to evaluate D-dimer negating time and its relationship with PT-INR. Methods: In this cross-sectional study, ۵۰ patients with VTE were included in the study. D-dimer was measured by the ELISA method in patients. The criterion for the D-dimer negating having a level below ۵۰۰ μg in hospitalized patients with pulmonary embolism and DVT. The relationship between D-dimer negating time and INR was analyzed using ANOVA and Pearson correlation tests.Results: The minimum and maximum time for the D-dimer to be negative is seven and ۷۱ days, respectively. The mean duration of D- dimer negating time in all patients was ۲۵.۰۸ ۱۵±۱۵.۲ days. The mean duration of D-dimer negating time was ۲۲.۱۸±۶/۷ days among ۱۲ patients with INR < ۲ and ۲۲.۹۲ ± ۱۳.۹ days among ۲۴ patients with INR < ۳, and ۳۲/۴۲±۲۱/۲ days among ۱۴ patients with INR ≥۳. There was a statistically significant difference between different INR groups (p-value: ۰.۰۴۹). Conclusion: The results showed a direct relationship between INR in thromboembolic patients and the duration of D-dimer negating time. The correlation of PT-INR and D-dimer negation time in patients of venous thromboembolism was found and thus D-dimer negation time also can serve as another marker of warfarin control.

کلیدواژه ها

D-dimer, INR, Venous thromboembolism, Deep vein thrombosis, Pulmonary embolism

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.