Crocus sativus (saffron) in the treatment of female sexual dysfunction: a three-center, double-blind, randomized, and placebo-controlled clinical trial
- سال انتشار: 1401
- محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 12، شماره: 3
- کد COI اختصاصی: JR_AJP-12-3_005
- زبان مقاله: انگلیسی
- تعداد مشاهده: 145
نویسندگان
Infertility Ward, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran
Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Canada
Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
Infertility Ward, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran
Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Objective: One of the traditional aphrodisiacs used in various cultures is Crocus sativus, commonly called saffron. Previous studies have pointed to the possible applicability of saffron for sexual dysfunction in both men and women. This study investigates the effects of saffron capsules on female sexual dysfunction.Materials and Methods: This study was a parallel-group, double-blind, randomized, placebo-controlled clinical trial. Participants, who were married women between ۱۸ and ۵۵ years of age suffering from severe sexual dysfunction, were randomized to receive either ۱۵ mg Crocus sativus capsules twice daily or placebo. The treatment continued for ۶ weeks, and patients were evaluated every ۲ weeks. The primary outcome was the change in the female sexual function index score. Other outcomes included the female sexual function index sub-domains.Results: Seventy-four patients were equally randomized to each group, and ۳۴ in each group completed the trial. Participants in both groups experienced improved total scores at each visit. However, a repeated-measures ANOVA revealed that time ´ treatment differed between groups in favor of the saffron group (p=۰.۰۵۰). During the ۶th week follow-up, the saffron group had a ۶۲% score improvement from baseline. Desire, lubrication, and satisfaction were female sexual function index domains in which saffron demonstrated superiority over placebo. The adverse event profile was similar for the groups, and no participant discontinued treatment.Conclusion: Findings of this study suggest that saffron might be a safe and effective option to ameliorate female sexual dysfunction. Further robust research is warranted.کلیدواژه ها
Crocus sativus, Randomized controlled trial, Saffron, Sexual dysfunctionاطلاعات بیشتر در مورد COI
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