A Novel Subset of Triple-Negative Breast Cancers with Unique Histology and Immunohistochemical Expression
- سال انتشار: 1401
- محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 17، شماره: 2
- کد COI اختصاصی: JR_IJP-17-2_013
- زبان مقاله: انگلیسی
- تعداد مشاهده: 564
نویسندگان
Tirunelveli Medical College, Tamilnadu, India
Tirunelveli Medical College, Tamilnadu, India
Tirunelveli Medical College, Tamilnadu, India
Tirunelveli Medical College, Tamilnadu, India
Tirunelveli Medical College, Tamilnadu, India
چکیده
Background & Objective: Triple-Negative Breast Carcinoma (TNBC) is characterized by an absence of estrogen receptor, progesterone receptor and HER۲ neu expression, with distinct molecular, histological and clinical features, aggressive clinical course and a poor prognosis. The objective was to evaluate the expression of Cytokeratin۵/۶ (CK ۵/۶), Epidermal Growth Factor Receptor ۱ (EGFR ۱), E-cadherin and Androgen receptor in tissue sections of TNBC.Methods: All modified radical mastectomy samples received negative for the three markers were subjected to further studies with CK۵/۶, EGFR ۱, E- cadherin and Androgen receptor staining. The clinical and pathological data were tabulated and statistically analysed using the Chi-square test, and cross-tabulation was done to assess the correlation between these markers.Results: Of ۹۴ samples classified as TNBC, ۳۱ (۳۳%) were positive for CK ۵/۶, ۴۷ (۵۰%) for EGFR, ۳۲ (۳۴%) for E Cadherin and Androgen receptor, respectively. We had one positive patient for all four markers, ۱۳ patients were negative for all four. Thirty-five cases were positive for only one marker, ۳۲ were positive for two markers, and ۱۳ were positive for three markers. Analysis revealed certain interesting patterns, namely - E cadherin was the most common isolated marker expressed in our cohort of TNBC with ۱۵ of ۳۵ positives.Conclusion: This study highlights the presence of a unique subtype of TNBC, which are negative for all the four markers studied here, with unique histomorphology of absent tumour necrosis and stromal lymphocytic infiltration being unique.کلیدواژه ها
Androgen receptor, Breast cancer, CK ۵/۶, EGFR, E- cadherin, Triple-negativeاطلاعات بیشتر در مورد COI
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