Inhibitory effects of Ficus carica and Olea europaea on pro-inflammatory cytokines: A review

  • سال انتشار: 1401
  • محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 25، شماره: 3
  • کد COI اختصاصی: JR_IJBMS-25-3_001
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 294
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نویسندگان

Lotfollah Rezagholizadeh

Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

Maryam Aghamohammadian

School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

Mahya Oloumi

School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

Shokofeh Banaei

Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

Mohammad Mazani

Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

Masoud Ojarudi

Department of Biochemistry, Faculty of Sciences, Payame Noor University, Tehran, Iran

چکیده

Objective(s): Ficus carica (fig) and Olea europaea (olive) are valuable nutritional plants that are widely used in diet and traditional medicine. Different parts of the plants such as fruit and leaves contain beneficial compounds with diverse pharmacological properties, among which anti-inflammatory activities are remarkable. The purpose of this review is to discuss the anti-inflammatory effects of F. carica and O. europaea with emphasis on their impact on pivotal pro-inflammatory cytokines including IL-۱, IL-۶, and TNF-α. Materials and Methods: To prepare the present review, the sites utilized included Scopus, PubMed, Science Direct, and Google Scholar and studied relevant articles from ۲۰۰۰ until ۲۰۲۱. Results: As a result, we observed that most of the compounds in fig and olive including polyphenols, flavonoids, etc., exert their anti-inflammatory effects through inhibiting or decreasing pro-inflammatory cytokines. Moreover, some natural antioxidants are common between these two plants. Conclusion: We suggest that consuming figs and olives simultaneously or alone can be useful in the prevention or treatment of inflammatory diseases.

کلیدواژه ها

Cytokine, Ficus carica, Inflammation, Olea europaea, TNF-α

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