Investigation on the Relationship between D-Dimer and Cell Blood Count Indices in COVID-۱۹ Prognosis: A Retrospective Study on ۳۲۰ COVID-۱۹ Patients

  • سال انتشار: 1401
  • محل انتشار: مجله ایمنی و بهبود بیمار، دوره: 10، شماره: 1
  • کد COI اختصاصی: JR_PSQ-10-1_002
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 271
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نویسندگان

Najmeh Majidi

Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Hamed Majidi

Bachelor of Science, Ferdowsi University of Mashhad, Mashhad, Iran.

چکیده

Introduction:Due to the spreading of coronavirus infection in ۲۰۱۹ (COVID-۱۹) throughout the world, tracking cell blood count (CBC) of moderate to severe COVID-۱۹ patients could provide new insights for the prognosis prediction.Materials and Methods: In this observational-retrospective study, D-dimer and CBC documents of ۳۲۰ confirmed COVID-۱۹ patients hospitalized in Shamsoshomus Clinic, Mashhad, Iran, were evaluated. Receiver operation characteristics (ROC) curve was analysed to determine specificity and sensitivity of D-dimer and hematological indices, including white blood cell (WBCs), lymphocytes, monocytes, eosinophil, red blood cell width (RDW), platelets (PLT), and mean of platelet volume (MPV). Results: This study included ۱۵۷ (۴۹.۱%) male and ۱۶۳ (۵۰.۳%) female COVID-۱۹ patients between ۱۴ to ۹۶ years old. According to their status in the duration of hospitalization, patients were considered in the good outcome group (N=۲۱۵) and poor outcome group (N=۱۰۵). A significant difference was observed in D-dimer, WBCS, PMN, Lymph, monocytes, eosinophil, and RDW between the two groups (P< ۰.۰۰۱). The highest sensitivity and the lowest specificity belonged to RDW (۹۹%, ۴%), WBCs (۹۸%, ۴%), PMN (۹۹%, ۱۱%) and D-dimer (۹۶%, ۴۲%). D-dimer indicated a significant association with WBCs, PMN, and RDW (P< ۰.۰۵).Conclusion:The present study revealed that WBCs and RDW might be recommended for the COVID-۱۹ prognosis prediction due to their high comparable sensitivity to D-dimer.

کلیدواژه ها

Cell Blood count, COVID-۱۹, Prognosis Red blood cell width, white blood cell, sensitivity, specificity

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