Exosomes as A Next-Generation Drug Delivery Sys-tem: An Update on Drug Loading Approaches and Char-acterization

سال انتشار: 1399
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 142

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شناسه ملی سند علمی:

RROYAN21_004

تاریخ نمایه سازی: 14 فروردین 1401

چکیده مقاله:

Exosomes are small nanoparticles secreted by almost all cells and have a well-known role in intercellular communication. They are found in different body fluids and can also be isolated from cell culture media. They contain a natural cargo includ-ing various protein and nucleic acid molecules originated from their donor cells. In recent years, exosomes provide a great potential as drug delivery and theranostic systems. They are believed to provide a targeted delivery of drug molecules, sup-plemented with their natural function. Furthermore, they have a membranous structure similar to liposomes, and that motivated researchers to apply their previous experience of drug load-ing into liposomes for exosomes. Herein, we discuss applied methods for the encapsulation of different drugs into exosomes, parameters affecting the incorporation of drug molecules into exosomes, characterization techniques, recent achievements, commercialization challenges and the potential future devel-opments of exosomal drugs. Overall, while the application of exosomes as a drug delivery system is still in its infancy, they are considered to be a new class of natural nanocarriers with great potential for clinical application. Understanding of their key formulation parameters, pharmaceutical properties, in vivo behavior and applicable scale-up production will pave their way to the market.

نویسندگان

A Haeri

Department of Pharmaceutics and Pharmaceutical Nanotechnol-ogy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran