Assessment of Human Leukocyte Antigen Differences between Smokers with Reinke’s Edema and Those with Laryngeal Cancer

Introduction:The present study aimed to assess human leukocyte antigen (HLA) typing differences between smokers with Reinke’s edema and those with laryngeal squamous cell carcinoma (SCC). Materials and Methods:The HLA class I, II alleles were examined in ۷۶ unrelated Iranian patients using low-resolution polymerase chain reaction with the sequence-specific primer (PCR-SSP) method. Results:The frequency of the HLA-A*۳۶ allele and HLA-B*۳۵ was significantly higher in patients with SCC. The frequency of HLA-DRB۱*۰۱ alleles in Reinke’s edema was significantly higher, as compared to that in others. In the volunteer group, HLA-DRB۱*۱۳ and HLA-DRB۱*۱۵ were significantly higher. Conclusions:As evidenced by the obtained results, HLA-A*۳۶ was significantly higher in SCC, as compared to that in volunteers and Reinke’s edema patients. It can be concluded that being positive for HLA-A*۳۶ increases the chance of SCC by three times. This result should be further investigated in cohort studies conducted on larger samples. Furthermore, HLA-A*۲۴ was significantly higher in the volunteer group, as compared to that in other groups. The HLADRB۱*۰۱ was remarkably higher in Reinke’s edema, as compared to that in SCC.

کلیدواژه ها:

Human leukocyte antigen ، Hypertrophic edema ، Iranian ، Polymerase chain reaction sequence-specific primers ، Reinke’s edema