Plasma Influence of Surface Texture of Silicone Rubber for Biomedical Application in Scala Tympani
- سال انتشار: 1400
- محل انتشار: فصلنامه مواد پیشرفته و فرآوری، دوره: 9، شماره: 2
- کد COI اختصاصی: JR_JMATPR-9-2_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 123
نویسندگان
New Hearing Technologies Research Center, Baqiyatallah University of Medical Sciences; Tehran, Iran
Department of Otorhinolaryngology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Department of Biopolymer, Faculty of Polymer Engineering, Amir Kabir University of Technology, Tehran, Iran
Department of Biocompatible Polymers, Iran Polymer and Petrochemical Institute (IPPI), Tehran, Iran
چکیده
This study aims to fabricate an optimum interface surface for intracochlear catheter applications. The samples were first fabricated of two-component liquid dimethyl siloxane by designing and fabricating a mold, and then the assembly underwent surface treatment using a plasma irradiation device. The water contact angle test results showed an increase in the surface hydrophilicity of this material that water drop contact angle of origin silicone is ۱۰۵° that after treatment decrease to ۶۰°, which has the property of reducing the effect of cellular cutting in the inner ear when passing through the scala tympani. The surface engagement during passage was also minimized with an increase in surface roughness at the nanoscale. SEM and AFM photomicrographs and nano graphs show that the morphology of catheter surface in nanoscale changed and roughness increased, which is desirable for this purpose. The cell viability test results showed an improved adhesion and cell growth on the modified surface and origin silicone, and ۹۵ % viability of cells confirmed, indicating the optimal biocompatibility of the modified silicone sample. This catheter can be used in cochlear implantation and drug delivery before surgery to enhance therapeutic efficiencyکلیدواژه ها
Polydimethylsiloxane (PDMS), Plasma, Catheter, Scala Tympani, Neurotrophinاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.