Lavender protects H۹c۲ cardiomyocytes against oxygen-glucose deprivation (OGD)-induced injury via targeting the JAK۲/STAT۳ pathway
- سال انتشار: 1401
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 25، شماره: 2
- کد COI اختصاصی: JR_IJBMS-25-2_017
- زبان مقاله: انگلیسی
- تعداد مشاهده: 345
نویسندگان
Institut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, ۷۱ Avenue des Martyrs, ۳۸۰۰۰ Grenoble, France
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
چکیده
Objective(s): This study was conducted to examine the therapeutic effects of lavender oil (LO) against oxygen-glucose deprivation (OGD)-induced injury in vitro model.Materials and Methods: In this study, the OGD model was induced in the H۹C۲ cell line, and then the cells were treated with LO (۱۰, ۱۰۰, ۱۰۰۰, and ۱۰۰۰۰ μg/ml). The anti-inflammatory activity of LO (Jak۲/Stat۳) was evaluated by immunocytochemical assay. Likewise, the p-ERK/ERK level was measured by western blotting.Results: Compared with only the OGD-induced injury model, cell survival increased after treatment with LO. Our results showed that ۱۰۰ μg/ml of LO significantly decreased the expression of Jak۲/Stat۳ and the apoptotic activity ۷۲ hr after reperfusion compared with the control group. Likewise, significant increases were observed in p-ERK/ERK in LO-treated groups. Conclusion: Collectively, these findings confirm that LO can be a good candidate to reduce OGD-induced injury in the H۹C۲ cell line through targeting Jak۲/Stat۳ and ERK pathways.کلیدواژه ها
H۹C۲ cells, Inflammation, Ischemia/Reperfusion injury, Jak۲ / Stat۳, Lavender oil, p-ERK / ERKاطلاعات بیشتر در مورد COI
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