Lectin-Like OLR۱ ۳′UTR Rs۱۰۵۰۲۸۶ Gene Polymorphism and Plasma Oxidized-LDL in Coronary Artery Disease and Their Relation to Cardiovascular Risk and Outcomes
- سال انتشار: 1400
- محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 10، شماره: 4
- کد COI اختصاصی: JR_RBMB-10-4_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 189
نویسندگان
Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Anesthesia, ICU and Pain Relief, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
چکیده
Background: Oxidized low-density lipoprotein (ox-LDL) has an important role in the genesis of coronary atherosclerosis. Lectin-like ox-LDL receptor ۱ (OLR۱) contributes to the uptake and internalization of ox- LDL. Genetic polymorphisms have been associated with coronary artery disease (CAD). Here we explore the association of plasma levels of ox-LDL and ۳′ UTR OLR۱ (rs۱۰۵۰۲۸۶) SNP with CAD risk and inhospital adverse outcomes. Methods: A case-control study enrolled ۱۹۲ patients with ST-segment elevation myocardial infarction (STEMI), ۱۰۰ patients with unstable angina, and ۱۰۰ healthy controls. Baseline, clinical characteristics, and risk scores of the patients were determined. Plasma ox-LDL and other biochemical variables were measured. All subjects are genotyped for OLR۱ (rs۱۰۵۰۲۸۶) by RT-PCR with TaqMan SNP genotyping assay. Results: Plasma ox-LDL was higher with enhanced sensitivity and specificity in identifying patients with STEMI and was found as a significant independent risk factor for CAD in those two groups. Levels of ox-LDL were increased with increasing poor prognostic factors in STEMI patients that are associated with an increased incidence of some adverse events and in-hospital mortality. Elevated STEMI risk was associated with T allele of OLR۱ (rs۱۰۵۰۲۸۶) (odds ratio of ۴.۹, ۹۵% CI: ۲.۶-۹.۴, p< ۰.۰۰۱). STEMI patients who have T allele exhibited higher risk scores, coronary multivessel narrowing, and elevated incidence of in-hospital major adverse clinical events. Conclusions: These results suggest that plasma ox-LDL, as well as T allele of ORL-۱ (rs۱۰۵۰۲۸۶), is associated with the increased risk for developing STEMI and the associated adverse clinical outcomes.کلیدواژه ها
Coronary artery disease, genotyping, OLR۱, outcomes, Oxidized low-density lipoprotein.اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.