The Cytokines Responses against Parvovirus B۱۹ in Miscarriage Women and the Susceptibility of their RhD Blood Type to Contract Parvovirus B۱۹ in South of Iraq
- سال انتشار: 1400
- محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 10، شماره: 3
- کد COI اختصاصی: JR_RBMB-10-3_015
- زبان مقاله: انگلیسی
- تعداد مشاهده: 168
نویسندگان
Department of Pathological Analysis, College of Science, University of Thi-Qar,Thi-Qar, Iraq.
Iraq. ۲: Department of Medical Laboratory Technique, Al-Nasiriyah Technical Institute, Southern Technical University, Thi-Qar, Iraq.
Department of Laboratory, Rizgary Teaching Hospital, Erbil, Kurdistan Region, F.R. Iraq.
Department of Physiology, College of Medicine, University of Thi-Qar, Thi-Qar, Iraq.
Department of clinical laboratory, College of Applied Medical Science, University of Hail, Hail, Saudia Arabia.
چکیده
Background: Parvovirus B۱۹ (B۱۹) infection is linked with various diseases. Cytokines play critical roles in cellular response to viral infection. It has also been reported that’s susceptibility of the ABO blood type people to several viral infection. In this study, we evaluated interleukin ۶ (IL-۶), interleukin ۸(IL-۸), and interferon gamma (IFN-γ) levels in aborted women infected with parvovirus B۱۹ (B۱۹+/Abr+) and uninfected with B۱۹(B۱۹-/Abr+) in comparison with healthy women (B۱۲-/Abr-) and susceptibility of their RhD blood type to contract B۱۹. Methods: B۱۹+/Abr+ were diagnosed using IgM and IgG antibodies against B۱۹, and the concentrations of IL-۶, IL-۸, and IFN-γ were determined using enzyme-linked immunosorbent assay (ELISA) test in both B۱۹+/Abr+, B۱۹-/Abr+, and B۱۹-/Abr-. Here, we also collected blood groups, number of abortion, and gestational ages from ۲۰۰ B۱۹+/Abr+ along with the same number ofB۱۹-/Abr+ and B۱۹-/Abr-. Results: The levels of IFN-γ were higher in serum of B۱۹-/Abr+andB۱۹+/Abr+ group in comparison to B۱۹-/Abr-, while the serum levels of IL-۶, IL-۸were increased in B۱۹+/Abr+ group in comparisontoB۱۹-/Abr+ and B۱۹-/Abr-. Our analyzed data also showed that aborted women with RhD+ are more susceptible to contract s B۱۹ than people with RhD- blood type. Conclusions: B۱۹ infection may differently modulate the amount of cytokines in the plasma of aborted women. So, it can be suggested that IL-۶, IL-۸, and IFN-γ potentially useful as markers for inflammation intrauterine. The susceptibility/protection of aborted women against B۱۹ might be determined based on RhD blood type.کلیدواژه ها
Aborted women, IL-۶, IL-۸, IFN-γ, Parvovirus B۱۹, RhD blood type.اطلاعات بیشتر در مورد COI
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