Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats
- سال انتشار: 1400
- محل انتشار: علوم اعصاب کاسپین، دوره: 7، شماره: 4
- کد COI اختصاصی: JR_CJNS-7-4_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 204
نویسندگان
Department of Anatomy, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Department of Anatomy, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Department of Anatomy, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Department of Anatomy, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
چکیده
Background: Aortic artery stenosis leads to Ischemia-Reperfusion (I-R) injury, which can cause certain clinical expressions, such as paraplegia. Objectives: To appraise the effect of Catechin Hydrate (CH) against spinal cord I-R injury. Materials & Methods: A total of ۳۵ male rats (۲۵۰-۳۰۰ g) were divided randomly into five groups: intact, sham surgery, dimethyl sulfoxide (I-R+DMSO), low-dose CH (I-R+۱۰ mg/kg CH), and high-dose CH (I-R+۲۰ mg/kg CH). Abdominal aorta clamping was done for ۶۰ min. Seventy-two hours after I-R, animals were evaluated for neurologic function, biochemical analysis, and histology. The data analysis was conducted by SPSS v. ۱۶ using ANOVA and Kruskal-Wallis and Mann-Whitney U tests. Results: The mean Motor Deficit Index (MDI) score and white matter damage in the CH (۲۰ mg/kg) group were lower than in the DMSO group (P=۰.۰۳۲). The mean plasma levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in the CH groups were lower than that of the DMSO group (P< ۰.۰۵). The plasma level of Total Antioxidant Capacity (TAC) in the CH (۲۰ mg/kg) group was higher than in the DMSO group (P=۰.۰۳۲). In addition, the plasma level of catalase in the CH (۲۰ mg/kg) group was higher than in the DMSO and CH (۱۰ mg/kg) groups (P< ۰.۰۰۱). The average number of normal motor neurons in the experimental groups was lower than in the sham surgery group (P< ۰.۰۰۱). Conclusion: These results showed that CH may be effective in reducing spinal cord I-R injury.کلیدواژه ها
Spinal cord injuries, Antioxidants, Ischemia, Reperfusion, Ratsاطلاعات بیشتر در مورد COI
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