Kindlin۱ As a Sex and Location Specific Diagnostic Marker in Gastric Cancer Patients
- سال انتشار: 1401
- محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 17، شماره: 1
- کد COI اختصاصی: JR_IJP-17-1_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 331
نویسندگان
Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background & Objective: Gastric cancer (GC) is considered one of the main reasons for cancer-related mortalities among Iranians. Kindlin-۱ is an adhesion protein member of integrin-interacting proteins, regulating integrin activation through direct interaction with β-integrin. Therefore, kindlin-۱ can be involved in the regulation of cell proliferation and adhesion. In the present study, we assessed the possible role of kindlin-۱ in GC progression and metastasis.Methods: KINDLIN۱ messenger RNA (mRNA) expression was assessed in tumor tissues from ۸۰ GC patients in comparison with normal tissues using real-time polymerase chain reaction (PCR).Results: The levels of KINDLIN۱ expressions were significantly correlated with sex (P=۰.۰۵) and tumor location (P=۰.۰۰۲). KINDLIN۱ expression was also significantly associated with lymph node metastasis among the helicobacter pylori (HP)-negative cases (P=۰.۰۰۱). Moreover, a significant association between age and KINDLIN۱ expression was observed among the HP-positive cases (P=۰.۰۳۹).Conclusion: In the present study, we introduced KINDLIN۱ as a location-specific marker for cardia gastric carcinoma. Moreover, it was observed that KINDLIN۱ could be used as a sex-dependent diagnostic marker of GC patients.کلیدواژه ها
Gastric Cancer, Cell adhesion, Integrin, Helicobacter pylori, Extra Cellular Matrixاطلاعات بیشتر در مورد COI
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