The Nasal Smear for Eosinophils, Its Value, and Its Relation to Nasal Mucosal Eosinophilia in Allergic Rhinitis
- سال انتشار: 1389
- محل انتشار: مجله علمی گوش و حلق و بینی ایران، دوره: 22، شماره: 3
- کد COI اختصاصی: JR_IJOTO-22-3_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 190
نویسندگان
Ear, Nose, Throat Research Center, Department of otorhinolaryngolgy , Mashhad University of Medical Sciences, Mashhad, Iran
Birjand University of Medical Sciences, Birjand, Iran
Department of pathology, Mashhad University of Medical Sciences, Mashhad, Iran
Immunology Research Center, Department of immunobiochemistery, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Introduction: There is no single test as a gold standard for the diagnosis of allergic rhinitis (AR). The aim of this study was to assess the usefulness and validity of nasal smear as a quick, easy and inexpensive diagnostic method for diagnosis of allergic rhinitis. Materials and Methods: This study was conducted in a university hospital setting. Nasal smears were taken from ۳۹ patients with a clinical history of nasal allergy and a positive skin prick test to at least one aeroallergen as well as ۲۶ controls without any history and negative test. Biopsy specimens from the inferior turbinate as well as nasal smears of ۱۹ cases including ۹ patients and ۱۰ controls with the same criteria were taken. Nasal smears and biopsy slides were stained with Giemsa and Hematoxilin-Eosin and were examined blindly by two separate pathologists. Results: Fifty one percents of the patients and ۱۱.۵% of the controls showed eosinophilia in their nasal smear (≥۱۰% eosinophils, P=۰.۰۰۱). The sensitivity of nasal eosinophil count as a diagnostic test for AR was ۵۱.۳% with a specificity of ۸۸.۵%, a positive predictive value of ۸۷% and a negative predictive value of ۵۴%. Eosinophilia in nasal biopsies was found in ۴۴% and ۳۰% of allergic patients and controls respectively. There was no significant correlation between symptoms or positive skin tests with either smear eosinophilia or tissue eosinophilia. Conclusion: Evaluation of eosinophils in nasal smear is an insensitive but fairly specific test for the diagnosis of allergic rhinitis. It seems that the nasal secretions and nasal tissue represent two distinct cellular compartments.کلیدواژه ها
Eosinophilia, Nasal mucosa, Rhinitisاطلاعات بیشتر در مورد COI
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