Mehdi Bakhshaee - Sinus and Surgical Endoscopic Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Farahzad Jabari - Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Mehdi Ghassemi - Sinus and Surgical Endoscopic Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Shiva Hourzad - Medical Student, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Russell Deutscher - Medical Student, Caribbean Medical University, Curacao.
Kianoosh Nahid - Department of Otorhinolaryngology, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Chronic rhinosinusitis (CRS) is a multifactorial disease. Allergies are considered a predisposing factor to CRS; however, this remains controversial. The objective of this research was to investigate the prevalence of co-morbidities and allergic reaction, and to specify the most common allergens in patients with confirmed CRS.   Materials and Methods: One hundred patients with signs and symptoms of CRS who met the diagnostic endoscopic and radiologic criteria of chronic rhinosinusitis were selected. They filled out a questionnaire and underwent a skin prick test for the common inhalant allergens. Allergic rhinitis was diagnosed according to the history and positive skin prick tests.   Results: The mean age of patients was ۳۴. Males were slightly more involved (۵۴%). The prevalence of polypoid and none-polypoid rhinosinusitis was ۵۴% and ۴۶% respectively. The patients’ most common symptoms were nasal discharge (۹۵%), blockage (۹۴%), smell disorders (۶۳%), cough (۴۵%), halitosis (۴۱%), lethargy (۳۷%), and aural fullness (۳۶%). Allergy to at least one allergen was noted in ۶۴% of the CRS patients which is higher than general population in Mashhad, Iran with allergic rhinitis (۲۲.۴%). Salsola was the most common allergen. There was no significant difference in allergic reactions between polypoid and non-polypoid CRS patients.   Conclusion:  Allergic reactions was found in Iranian CRS patients with or without polyposis to be much higher than general population in Mashhad with allergic rhinitis alone.

Allergy, Chronic Rhinosinusitis, Polyposis, Skin Prick Test